Physical inactivity is a significant and growing major health concern, and is defined as not engaging in any regular pattern of physical activity beyond that associated with daily functioning.1 The many consequences of inactivity include reductions in skeletal muscle insulin sensitivity and expansion of fat storage—factors associated with the development of obesity, the metabolic syndrome, and type 2 diabetes.2 Exercise is frequently performed with the goal of counteracting these changes, and enhancing health and life expectancy. Imagine if the health benefits of exercise could be produced simply by taking a so-called ‘exercise pill’. This would be every couch potato’s dream and may be a reality if a paper recently published in the prestigious journal Cell is any indication.
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