In this issue of the Journal, September et al. 1 have studied DNA variants within the COL5A1 gene among patients affected by Achilles tendinopathy (the cases) and among age- and country-of-origin-matched controls who have no tendinopathy (controls). Their findings suggest that common variation at the DNA level in the COL5A1 gene it may be a risk factor for Achilles tendinopathy. Replication of their results among larger cohorts will be necessary to validate this finding.
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