Background: Asthma is frequent in elite athletes and clinical studies in athletes have found increased airway inflammation.
Objective: To investigate asthma-like symptoms, airway inflammation, airway reactivity (AR) to mannitol and use of asthma medication in Danish elite athletes.
Methods: The study group consisted of 54 elite athletes (19 with physician-diagnosed asthma), 22 non-athletes with physician-diagnosed asthma (steroid naïve for 4 weeks before the examination), and 35 non-athletes without asthma; all aged 18-35 years. Examinations (one day): questionnaires, exhaled nitric oxide (eNO), spirometry, skin prick test, AR to mannitol and blood samples. Induced sputum was done in subjects with asthma.
Results: We found no difference in values for eNO, AR and atopy between 42 elite athletes with and 12 without asthma-like symptoms (NS). Elite athletes with physician-diagnosed asthma had less AR (Response Dose Ratio 0.02 (0.004) vs. 0.08 (0.018) p < 0.01) and fewer sputum eosinophils (0.8% (0-4.8) vs. 6.0% (0-18.5), p < 0.01) than non-athletes with physician-diagnosed asthma. Use of asthma medication was similar in the two groups (NS). Forty-two elite athletes had asthma-like symptoms but only 12 had evidence of current asthma. Elite athletes without asthma had asthma-like symptoms more frequently than non-athletes without asthma (68.6% vs. 25.7%, p < 0.001).
Conclusion: Asthma-like symptoms in elite athletes are not necessarily associated with classic features of asthma and alone should not give a diagnosis of asthma. More studies are needed to further investigate if and how the asthma phenotype of elite athletes differs from that of classical asthma.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.