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Br J Sports Med doi:10.1136/bjsm.2009.058040

Genetic Risk factors for soft tissue injuries 101: A Practical summary to help Clinicians understand the role of Genetics And ‘Personalised Medicine’

  1. Malcolm Collins (malcolm.collins{at}uct.ac.za)
  1. South African Medical Research Council and University of Cape Town, South Africa
    • Published Online First 23 June 2009

    Abstract

    Acute and chronic (overuse) musculoskeletal soft tissues injuries are common as a result of sports and occupational related physical activities. These injuries have no single cause -- instead, they result from a complex interaction of intrinsic and extrinsic factors which include genetic factors. Specific genetic elements have been identified for certain soft tissue injuries and I will summarise those in this editorial. I also explore the possible clinical implications of including genetic risk factors in multifactorial models developed to understand the molecular mechanisms of musculoskeletal soft tissue injuries.

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