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Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance
  1. Catalina Santiago
  1. Universidad Europea de Madrid, Spain
    1. Jonatan R Ruiz
    1. Karolinska Institutet, Sweden
      1. Amaya Buxens
      1. Progenika Biopharma, Spain
        1. Marta Artieda
        1. Progenika Biopharma, Spain
          1. David Arteta
          1. Progenika Biopharma, Spain
            1. Marta Gonzalez-Freire
            1. Universidad Europea de Madrid, Spain
              1. Gabriel Rodríguez-Romo
              1. INEF, Universidad Politécnica de Madrid, Spain
                1. Signe Altmäe
                1. Karolinska Institutet, Sweden
                  1. José I Lao
                  1. Sabiobbi S.L., Spain
                    1. Félix Gómez-Gallego
                    1. Universidad Europea de Madrid, Spain
                      1. Alejandro Lucia (alejandro.lucia{at}uem.es)
                      1. Universidad Europea de Madrid, Spain

                        Abstract

                        We compared allele and genotype frequencies of the ADRB1 Arg389Gly [rs1801253], ADRB2 Gly16Arg [rs1042713] and Gln27Glu [rs1042714], and ADRB3 Trp64Arg [rs4994] variations in the following three groups of Spanish (Caucasian) men: (i) world-class endurance athletes (E; runners and cyclists, N=100), (ii) elite power athletes (P; sprinters, jumpers and throwers, N=53) and (iii) non-athletic controls (C; N=100). We did not observe significant differences in genotype and allele distributions among the study groups except for the ADRB3 Trp64Arg polymorphism in E vs C (27% vs 8% of carriers of the Arg allele in E and C, P<0.001; frequency of the minor Arg (C) allele of 14% vs 4% in E and C, P=0.001). Heterozigosity for the ADRB3 Trp64Arg polymorphism seems to be associated with elite endurance performance, while other variants of the ß-adrenergic receptors’ genes do not seem to influence top-level sports performance significantly, at least in athletes of Spanish origin.

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