rss
Br J Sports Med doi:10.1136/bjsm.2009.061366

Trp64Arg polymorphism in ADRB3 gene is associated with elite endurance performance

  1. Catalina Santiago
  1. Universidad Europea de Madrid, Spain
    1. Jonatan R Ruiz
    1. Karolinska Institutet, Sweden
      1. Amaya Buxens
      1. Progenika Biopharma, Spain
        1. Marta Artieda
        1. Progenika Biopharma, Spain
          1. David Arteta
          1. Progenika Biopharma, Spain
            1. Marta Gonzalez-Freire
            1. Universidad Europea de Madrid, Spain
              1. Gabriel Rodríguez-Romo
              1. INEF, Universidad Politécnica de Madrid, Spain
                1. Signe Altmäe
                1. Karolinska Institutet, Sweden
                  1. José I Lao
                  1. Sabiobbi S.L., Spain
                    1. Félix Gómez-Gallego
                    1. Universidad Europea de Madrid, Spain
                      1. Alejandro Lucia (alejandro.lucia{at}uem.es)
                      1. Universidad Europea de Madrid, Spain
                        • Published Online First 23 June 2009

                        Abstract

                        We compared allele and genotype frequencies of the ADRB1 Arg389Gly [rs1801253], ADRB2 Gly16Arg [rs1042713] and Gln27Glu [rs1042714], and ADRB3 Trp64Arg [rs4994] variations in the following three groups of Spanish (Caucasian) men: (i) world-class endurance athletes (E; runners and cyclists, N=100), (ii) elite power athletes (P; sprinters, jumpers and throwers, N=53) and (iii) non-athletic controls (C; N=100). We did not observe significant differences in genotype and allele distributions among the study groups except for the ADRB3 Trp64Arg polymorphism in E vs C (27% vs 8% of carriers of the Arg allele in E and C, P<0.001; frequency of the minor Arg (C) allele of 14% vs 4% in E and C, P=0.001). Heterozigosity for the ADRB3 Trp64Arg polymorphism seems to be associated with elite endurance performance, while other variants of the ß-adrenergic receptors’ genes do not seem to influence top-level sports performance significantly, at least in athletes of Spanish origin.

                        This Article

                        1. Abstract
                        2. PDF

                        Responses

                        1. Submit a response
                        2. No responses published

                        Register for free content

                        The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

                        Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.