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Androgen receptor gene polymorphisms lean mass and performance in young men
  1. Amelia Guadalupe-Grau1,
  2. German Rodriguez-Gonzalez1,
  3. Cecilia Dorado1,
  4. Hugo Olmedillas1,
  5. Teresa Fuentes1,
  6. Jorge Perez-Gomez2,
  7. Safira Delgado-Guerra1,
  8. German Vicente-Rodríguez1,
  9. Ignacio Ara1,
  10. Borja Guerra1,
  11. Rafael Arteaga-Ortiz1,
  12. Jose A L Calbet1,*,
  13. Bonifacio Nicolas Diaz-Chico1
  1. 1 University of Las Palmas de Gran Canaria, Spain;
  2. 2 University of Extremadura, Faculty of Sport Science, Spain
  1. Correspondence to: Jose Antonio Lopez Calbet, Department of Physical Education, University of Las Palmas de Gran Canaria, Departmento de Educacion Fisica, Campus Universitario de Tafira, 35017 Las Palmas de Gran Canaria, Las Palams de Gran Canaria, 35017, Spain; lopezcalbet{at}gmail.com

Abstract

The exon-1 of the androgen receptor (AR) gene contains two repeat length polymorphisms which modify either the amount of AR protein inside the cell (GGNn, polyglycine) or its transcriptional activity (CAGn, polyglutamine). Shorter CAG and/or GGN repeats provide stronger androgen signalling, and vice versa. To test the hypothesis that CAG and GGN repeat AR polymorphism affects muscle mass and various variables of muscular strength phenotype traits, the length of CAG and GGN repeats was determined by PCR and fragment analysis, and confirmed by DNA sequencing of selected samples, in 282 men (28.6 ± 7.6 years). Individuals were grouped as CAG short (CAGS) if harbouring repeat lengths of ≤21 and CAG long (CAGL) if CAG >21. GGN was considered short (GGNS) or long (GGNL) if GGN ≤23 or > 23, respectively. No significant differences in lean body mass or fitness were observed between the CAGS and CAGL groups, or between GGNS and GGNL groups, but a trend for a correlation was found for the GGN repeat and lean mass of the extremities (r=-0.11, P=0.06). In summary, the length of CAG and GGN repeat of the AR gene do not appear to influence lean mass or fitness in young men.

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