Objectives: Seventeen male participants (age 33.5 ± 6.5 years [46-26 yrs], body mass 80 ± 9.2 kg [100-63 kg], height 1.81 ± 0.06 m [1.93-1.70 m]) ran a marathon to investigate the relationship between systolic function (using cardiac magnetic resonance; CMR) and diastolic function (using echocardiography) against biomarkers of cardiac damage.
Methods: Echocardiographic and cTnI/NT-pro-BNP data were collected 24h prior, immediately post- and 6h post-marathon. CMR data was collected 24h prior and at 6h post-marathon.
Results: Body mass was significantly reduced post-marathon (80 ± 9.2 vs. 78.8 ± 8.6 kg, p<0.001). There was a significant E/A reduction post-marathon (1.11 ± 0.34 vs. 1.72 ± 0.44; p<0.05), that remained depressed 6h post-marathon (1.49 ± 0.43; p<0.05). CMR demonstrated left ventricular (LV) end-diastolic and end-systolic volumes were reduced post-marathon, with a preserved stroke volume (SV). LV ejection fraction (EF) 6h post-marathon significantly increased (64.4% ± 4.2% vs. 67.4% ± 5%; p<0.05). There were significant elevations in cTnI (0.00 vs. 0.04 ± 0.03 μg/L; p<0.05) and NTproBNP (37.4 ± 24.15 vs. 59.34 ± 43.3; p<0.05) immediately post marathon. Eight runners had cTnI elevations immediately post-marathon above acute myocardial infarction cut off levels (AMI; ≥ 0.03 μg/L). No correlations between cTnI/NTproBNP and measures of diastolic function (E, A, E/A, IVRT, E deceleration time and E/E′) or measures of systolic function (SV or EF) were observed post- or 6h post marathon.
Conclusions: Biomarkers of cardiac damage following prolonged exercise are not associated with either systolic or diastolic functional measures.
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