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Acute changes in arginine vasopressin, sweat, urine and serum sodium concentrations in exercising humans: does a coordinated homeostatic relationship exist?
  1. T Hew-Butler1,
  2. T D Noakes1,
  3. S J Soldin2,
  4. J G Verbalis2
  1. 1University of Cape Town, Cape Town, South Africa
  2. 2Georgetown University Medical Center, Georgetown, Washington, DC 20007, USA
  1. Correspondence to Dr Tamara Hew-Butler, Department of Kinesiology, Arizona State University, Tempe, AZ 85287, USA; tamara.hew{at}overhydration.org

Abstract

The parallel response of sweat rate and urine production to changes in plasma osmolality and volume support a role for arginine vasopressin (AVP) as the main endocrine regulator of both excretions. A maximal test to exhaustion and a steady-state run on a motorised treadmill were both completed by 10 moderately trained runners, 1 week apart. Sweat, urine and serum sodium concentrations ([Na+]) were evaluated in association with the plasma concentrations of cytokines, neurohypophyseal and natriuretic peptides, and adrenal steroid hormones. When data from both the high-intensity and steady-state runs were combined, significant linear correlations were noted between: sweat [Na+] versus postexercise urine [Na+] (r=0.80; p<0.001), postexercise serum [Na+] versus both postexercise urine [Na+] (r=0.56; p<0.05) and sweat [Na+] (r=0.64; p<0.01) and postexercise urine [Na+] versus postexercise plasma arginine vasopressin concentration ([AVP]P) (r=0.48; p<0.05). A significant positive correlation was noted between postexercise [AVP]P and sweat [Na+] during the steady-state condition only (r=0.66; p<0.05). These correlations suggest that changes in serum [Na+] during exercise may evoke corresponding changes in sweat and urine [Na+], which are likely regulated coordinately by changes in [AVP]P to preserve body fluid homeostasis.

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Footnotes

  • Competing interests None.

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