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Longevity protein klotho is induced by a single bout of exercise
  1. Alana Santos-Dias1,2,
  2. BreAnne MacKenzie1,2,
  3. Manoel Carneiro Oliveira-Junior1,
  4. Rosa Maria Moyses2,3,
  5. Fernanda Marciano Consolim-Colombo2,
  6. Rodolfo Paula Vieira1,2
  1. 1Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University (UNINOVE) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São Paulo, Brazil
  2. 2Nove de Julho University (UNINOVE), São Paulo, Brazil
  3. 3Nephrology Division, School of Medicine, University of São Paulo, São Paulo, Brazil
  1. Correspondence to Professor Rodolfo Paula Vieira, Laboratory of Pulmonary and Exercise Immunology (LABPEI), Nove de Julho University (UNINOVE) and Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Rua Vergueiro 235/249, São Paulo 01504-001, Brazil; rodrelena{at}yahoo.com.br

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Physical activity clearly reduces disease-specific mortality in patients with diabetes.1 The mechanism responsible for reduced mortality appears to be linked to exercise-induced improvement in oxidation and reduction (redox) responses, as well as the halting or reversal of arterial and venal calcifications2 ,3 in diabetes-associated cardiovascular diseases (CVD)—currently the world's leading cause of mortality.4 A recent review established a relationship between decreased bioavailability of the protein klotho with CVD and with chronic kidney disease (CKD) disease states.5 Reduced levels of klotho are related to CVD and CKD complications, involving vascular calcification, inflammation, endothelial dysfunction and redox imbalance.5

Klotho is primarily expressed in the kidneys, but also found in other organs as well as cerebrospinal fluid, urine and blood.6 Reduced plasma levels of klotho are found in elderly persons, and klotho deficient mice display …

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