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Myokine: a novel target for exercise to improve cognitive function?
  1. Zhe-Cheng Jiang1,
  2. Ri-Yue Jiang2,
  3. Huan Li1,
  4. Bin Zhu3
  1. 1Department of Orthopedics, The Third Affiliated Hospital of Soochow University, Changzhou, China
  2. 2Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China
  3. 3Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, China
  1. Correspondence to Dr Bin Zhu, Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, No. 185 Juqian Street, Changzhou 213003, China; czzhubin{at}sina.cn

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Recently, we read with great interest the paper by Zheng et al,1 in which the authors who performed an excellent meta-analysis concluded that aerobic exercise had a physiological benefit to improve cognitive function in patients with mild cognitive impairment. We appreciate this finding and would like to present a hypothesis that myokine triggered by physical aerobic exercises might also play a pivotal role in the improvement of cognitive impairment.

Physical exercise is of great importance to the health of brain. Increasing evidence shows that regular exercise could increase the activity of skeletal muscle and, as a …

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