Article Text

PDF
Persistent effects of playing football and associated (subconcussive) head trauma on brain structure and function: a systematic review of the literature
  1. A A Tarnutzer1,2,
  2. D Straumann1,2,
  3. P Brugger1,
  4. N Feddermann-Demont1,2
  1. 1Department of Neurology, University Hospital Zurich and University of Zurich, Zurich, Switzerland
  2. 2Swiss Concussion Center, Schulthess Clinic, Zurich, Switzerland
  1. Correspondence to Dr A A Tarnutzer, Department of Neurology, University Hospital Zurich, Frauenklinikstr. 26, Zurich 8091, Switzerland; alexander.tarnutzer{at}access.uzh.ch, atarnutzer{at}gmail.com

Abstract

Aim/objective There is ongoing controversy about persistent neurological deficits in active and former football (soccer) players. We reviewed the literature for associations between football activities (including heading/head injuries) and decline in brain structure/function.

Design Systematic literature review.

Data sources MEDLINE, Embase, PsycINFO, CINAHL, Cochrane-CRCT, SportDiscus, Cochrane-DSR=4 (accessed 2 August 2016).

Eligibility criteria for selecting studies Original studies reporting on football-related persistent effects on brain structure/function. Results from neurocognitive testing, neuroimaging and EEG were compared with controls and/or correlated with heading frequency and/or head injuries. Methodological quality was rated for risk-of-bias, including appropriateness of controls, correction for multiple statistical testing and assessment of heading frequency and head injuries.

Results 30 studies with 1691 players were included. Those 57% (8/14) of case–control studies reporting persistent neurocognitive impairment had higher odds for inappropriate control of type 1 errors (OR=17.35 (95% CI (10.61 to 28.36)) and for inappropriate selection of controls (OR=1.72 (1.22 to 2.43)) than studies observing no impairment. Studies reporting a correlation between heading frequency and neurocognitive deficits (6/17) had lower quality of heading assessment (OR=14.20 (9.01 to 22.39)) than studies reporting no such correlation. In 7 of 13 studies (54%), the number of head injuries correlated with the degree of neurocognitive impairment. Abnormalities on neuroimaging (6/8 studies) were associated with subclinical neurocognitive deficits in 3 of 4 studies.

Summary/conclusions Various methodological shortcomings limit the evidence for persistent effects of football play on brain structure/function. Sources of bias include low-quality assessment of heading frequency, inappropriate control for type 1 errors and inappropriate selection of controls. Combining neuroimaging techniques with neurocognitive testing in prospective studies seems most promising to further clarify on the impact of football on the brain.

Statistics from Altmetric.com

Footnotes

  • Contributors AAT conceived of the study, designed the search strategy, selected suitable articles, extracted and analysed the data, drafted the manuscript and approved the final version of the manuscript. PB was involved in the analysis of the data, critically edited the manuscript and approved the final version of the manuscript. DS was involved in conceiving the study design, critically edited the manuscript and approved the final version of the manuscript. NF-D conceived of the study, was involved in designing the search strategy, selected suitable articles, critically edited the manuscript and approved the final version of the manuscript.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.