Skip to main content
SpringerLink
Log in

The effect of exercise and zinc supplement on the hematological parameters in rats

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

This study evaluates the consequences of a session of intensive short-duration exercise and Zn supplementation on different hematological variables. Forty male Wistar rats were divided into four groups (n=10): the first nonsupplemented, maintained at rest (R); the second nonsupplemented, undergoing exercise (E); the third supplemented with Zn, kept at rest (ZnR); and the fourth supplemented with Zn, undergoing exercise (ZnE). Zinc supplements (200 ppm) were given in drinking water. The exercise consisted of a single session of swimming until exhaustion. At rest, RBC, Hb, and Hto fell (p<0.05), whereas red cell indices, MCV, and MCH rose (p<0.05) in +ZnR compared with R; MCHC remained unchanged (ZnR vs R). After exercise, RBC, Hb, and Hto increased significantly in E and in ZnE compared with R and ZnR, respectively. In addition, RBC and Hb were lower (p<0.01) in ZnE compared with E; however, MCV and MCH were higher (p<0.05) in the group ZnE vs E. With respect to white blood cells—leukocytes (WBC), limphocytes (LYMPH), and neutrophiles (NEUT)—no significant differences were observed between groups at rest (ZnR vs R). WBC and LYMPH increased significantly in E with respect to the rest situation (E vs R), but this did not happen in supplemented animals (ZnE vs ZnR). Level of pH decreased after exercise both in E and in ZnE, but the fall was lower in the latter. We believe that a single session of swimming until exhaustion leads to an increase in RBC, Hb, and Hto without causing changes in MCV, MCH, and MCHC. On the other hand, Zn supplementation leads to an increase of MCV and MCH, although they remain within normal levels. Furthermore, this supplementation produces lower metabolic acidoses after exercise that leads to leukocyte stability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. W. Van Beaumont, J. C. Strand, J. S. Petrofsky, S. G. Hipskind, and J. E. GreenleafJ. Appl. Physiol. 34, 102 (1973).

    PubMed  Google Scholar 

  2. M. Gimenez, T. Mohan-Kumar, J. C. Humbert, N. De Talance, and J. Buisine,Eur. J. Appl. Physiol. 55, 465 (1986).

    Article  CAS  Google Scholar 

  3. D. B. Dill and D. L. Costill,J. Appl. Physiol. 37, 247 (1974).

    PubMed  CAS  Google Scholar 

  4. J. E. Wilkerson, M. A. Kolka, and L. A. Stephenson,Med. Sci. Sport 11, 99 (1979).

    Google Scholar 

  5. H. Naveri, K. Koupassalmi, and M. Harkonen,Int. J. Sports. Med. 6, 276 (1985).

    PubMed  CAS  Google Scholar 

  6. C. L. Wells, J. R. Stern, and L. H. Hecht,Eur. J. Appl. Physiol. 48, 41 (1982).

    Article  CAS  Google Scholar 

  7. E. Ernst,Eur. Health. J. 8, 59 (1987).

    Google Scholar 

  8. J. L. Puhl and W. S. Runyan,Res. Q. Exer. Sport 51, 533 (1980).

    CAS  Google Scholar 

  9. W. Hasibeder, W. Schobersberger, and H. Mairlbaurl,Int. J. Sports. Med. 8, 105 (1987).

    Article  PubMed  CAS  Google Scholar 

  10. J. Brotherhood, B. Brozovic, and L. G. C. Pugh,Clin. Sci. Mol. Med. 48, 139 (1975).

    PubMed  CAS  Google Scholar 

  11. Anonimus,Nutr. Rew. 43, 148 (1985).

  12. G. R. Lee, D. M. Williams, and G. E. Cartwright, inTrace Elements in Human Health and Disease, Academic Press, New York, 1976, pp. 373–402.

    Google Scholar 

  13. H. A. Ragan, S. Nacht, G. R. Lee, C. R. Bishop, and G. E. Cartwright,Amer. J. Physiol. 217, 1320 (1969).

    PubMed  CAS  Google Scholar 

  14. A. S. Prasad,Trace Elements and Iron in Human Metabolism, Plenum Medical, New York and London, 1979.

    Google Scholar 

  15. N. W. Solomons, O. Pineda, F. Viteri, and H. H. Sandstead,J. Nutr. 113, 337, (1983).

    PubMed  CAS  Google Scholar 

  16. R. J. Cousins,Physiol. Rev. 65, 238 (1985).

    PubMed  CAS  Google Scholar 

  17. C. L. Keen, R. M. Hackmann, inSport, Health and Nutrition: 1984 Olympic Scientific Congress Proceedings. Human Kinetics Publisher, Champaign, IL, 1986, pp. 45–56.

    Google Scholar 

  18. D. N. Dickson, R. L. Wilkinson, and T. D. Noakes,Int. J. Sports. Med. 3, 11 (1982).

    Google Scholar 

  19. C. L. Wells, J. R. Stern, W. M. Kohrt, and K. D. Campbell,Med. Sci. Sports Exerc. 19, 137 (1987).

    PubMed  CAS  Google Scholar 

  20. M. A. Konstam, S. Tumeh, J. Wynne, J. R. Beck, J. Kozlowski, and B. L. Holman,Circulation 66, 638 (1982).

    PubMed  CAS  Google Scholar 

  21. J. D. Robertson, R. J. Maughan, and R. J. L. Davidson,Eur. J. Appl. Physiol. 57, 264 (1988).

    Article  CAS  Google Scholar 

  22. W. Schmidt, N. Maassen, F. Trost, and D. Boening,Eur. J. Appl. Physiol. 57, 490 (1988).

    Article  CAS  Google Scholar 

  23. W. Schmidt, N. Maassen, U. Tegtbur, and K. M. Braumann,Eur. J. Appl. Physiol. 58, 453 (1989).

    Article  CAS  Google Scholar 

  24. H. Mairlbaurl, W. Schobersberger, W. Hasibeder, G. Schawaberger, G. Gaesser, and K. R. Tanaka,Eur. J. Appl. Physiol. 55, 174 (1986).

    Article  Google Scholar 

  25. Z. Szygula,Sports Med. 10, 181 (1990).

    Article  PubMed  CAS  Google Scholar 

  26. M. L. Storey and J. L. Greger,J. Nutr. 117, 1434 (1987).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology and Biochemistry, University of Valladolid, School of Physioterapy, 42003, Soria, Spain

    Alfredo Cordova & Francisco José Navas

  2. Department of Biomedicine, University of Zaragoza, Faculty of Medicine, 50009, Zaragoza, Spain

    Jesús Fernando Escanero

Authors
  1. Alfredo Cordova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francisco José Navas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jesús Fernando Escanero
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cordova, A., Navas, F.J. & Escanero, J.F. The effect of exercise and zinc supplement on the hematological parameters in rats. Biol Trace Elem Res 39, 13–20 (1993). https://doi.org/10.1007/BF02783805

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02783805

Index Entries

Search

Navigation