The effects of prolonged peritendinous administration of PGE1 to the rat Achilles tendon: a possible animal model of chronic Achilles tendinopathy
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Animal model for tendinopathy
2023, Journal of Orthopaedic TranslationHistologic grading correlates with inflammatory biomarkers in tibialis posterior tendon dysfunction
2022, Foot and Ankle SurgeryCitation Excerpt :However, the link to painful symptoms from mechanical loading, microscopic injury and degeneration is currently unknown. While tendinopathy was once considered to be a non-inflammatory process, newer evidence suggest that pain-related inflammatory cytokines, matrix metalloproteases (MMPs), pain neurotransmitters and angiogenesis are highly associated with tendinopathy [5,8–10]. Also of interest are numerous studies that have demonstrated increased expression of pain neurotransmitters or receptors, such as glutamate, N-methyl-D-aspartate receptor type 1 (NMDAr1), substance P (SP), and calcitonin-gene-related-peptide (CGRP) in Achilles, patellar, extensor carpi radialis brevis, and carpal tunnel tendons [11–23].
Graphene-MoS<inf>2</inf> polyfunctional hybrid hydrogels for the healing of transected Achilles tendon
2022, Biomaterials AdvancesCitation Excerpt :These blocks were cut into 6 μm pieces and stained with Hematoxylin & Eosin (H&E) staining to assess the microscopic morphology and evaluate the repairing process. The slides were quantified by a semi-quantitative histopathological method according to a previously reported grading system by Movin et al. [48,49]. Eight parameters including fiber structure, fiber arrangement, regional variations in cellularity, rounding of the nuclei, increased vascularity, decreased collagen stainability, hyalinization and GAG content were assessed by a 0–3 grading scale: 0 (normal), 1 (slightly abnormal), 2 (moderately abnormal) and 3 (highly abnormal) for each slide.
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2015, Rheumatology: Sixth EditionMinocycline microspheres did not significantly improve outcomes after collagenase injection of tendon
2019, Journal of OrthopaedicsCitation Excerpt :Prior studies in our lab have demonstrated improved tendon strength and stiffness properties following weekly peripatellar injections of PGE2.19 However, repeated exposure of Achilles tendons to PGE1 has been associated with hypercellularity, proliferation of capillaries, and tendon degeneration.26 Thus, the findings observed in MIN group histologic sections may, in part, be the result of increased prostaglandin production, but these effects may be important for structural remodeling of tendons.