Original articlePreliminary findings on the effects of sex hormones on bone metabolism in anorexia nervosa☆
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2001, Endocrinology and Metabolism Clinics of North AmericaCitation Excerpt :A 1999 study of women with anorexia nervosa suggested that bone formation was reduced but bone resorption normal,122 whereas another study suggested that bone formation was decreased and bone resorption increased.20 Further analyses of bone turnover indices in women with hypothalamic amenorrhea and anorexia nervosa have also produced inconsistent results, with some data suggesting normal bone turnover and other data suggesting low bone formation that is uncoupled from bone resorption.49,68 A 1998 study of amenorrheic long-distance runners demonstrated reductions in bone turnover and, particularly, in bone formation.145
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This work was supported in part by Public Health Service Grant RR-00044 from the General Clinical Research Branch, Division of Research Resources, National Institutes of Health (R.E.K.) and NIH Grant AR28420 (J.E.P. and R.N.R.).