Author | Year | Main outcomes | Significance | Level of evidence | Adverse events |
---|---|---|---|---|---|
Lee et al 36 | 2015 | VAS (0–100) at 6, 12, 24 and 52 weeks | p<0.001 | 4 | 6 cases of mild swelling with spontaneous resolution within 2 weeks, 2 cases of joint effusion after 1 month, resolved within 1 months, not significant. 1 case of delayed elbow pain treated with tramadol and acetaminophen |
Modified mayo elbow performance index (MEPI) | p<0.001 | ||||
Largest defect area of common extensor origin tendon | p<0.001 (longitudinal and transverse) | ||||
Pascual-Garrido et al 41 | 2012 | Tegner | p=0.0061 | 4 | Not reported |
Lysholm | p=0.1043 | ||||
IKDC | p=0.047 | ||||
KOOS | |||||
Pain | p=0.2399 | ||||
Symptoms | p=0.0086 | ||||
ADL | p=0.0246 | ||||
Sport | p=0.0078 | ||||
QOL | p=0.0825 | ||||
SF-12 | |||||
Mental | p=0.5589 | ||||
Physical | p=0.438 | ||||
Ultrasound evaluation | NA. All patients had grade 2–3 before inoculation. 6/9 had grade 1 after 6 months, one patient had grade 3 | ||||
Hernigou et al 35 | 2014 | MRI assessment of cuff healing: | 4 | Not reported | |
Retears confirmed by MRI after 10 years Intervention: | p<0.05 BMSC 6/45 vs control 25/45 | ||||
No change of MRI healing grade after 10 years: | NA BMSC 34/45 vs control 6/45 2.2 | ||||
Mean cells success versus no success (retear): | |||||
Bone marrow mononuclear cells | p<0.01 Success: 4200±1900/cm3 vs no success: 1500±1200/cm3 | ||||
Progenitor cells | p<0.01 Success: 54 000+23 000/cm3 vs no success: 14000±9000/cm3 | ||||
Non-healing in the first 6 months: | NA 0/45 intervention vs 8/45 control | ||||
Ellera Gomez et al 34 | 2012 | UCLA score | NA, increase from 12 to 31 | 4 | Not reported |
MRI analysis | NA, 14 cases of full tendon integrity, 8/14 low signal intensity along supraspinatus, 11/14 high signal artefact at the bursal and tendon, 6/14 high signal intensity zone at the critical zone |
IKDC, International knee documentation committee; KOOS, Knee Injury and Osteoarthritis Outcome Score; NA, not available or applicable; SF-12, short form health survey 12; UCLA score, University of California at Los Angeles Shoulder rating scale; VAS, visual analogue scale.