Table 4

A multivariable adjusted model exploring prognostic factors for patient-reported outcomes at 5 years for the exercise therapy plus delayed reconstruction group

Effect95% CIp ValueEffect95% CIp ValueEffect95% CIp ValueEffect95% CIp Value
Baseline cartilage defect2.7−11.2 to 16.50.680.0−23.1 to 23.11.0012.7−19.8 to 45.30.418.9−19.1 to 36.80.50
Baseline meniscus damage14.30.7 to−18.4 to 27.20.6827.4−3.8 to 58.70.0822.8−5.0 to 50.50.10
Baseline osteochondral lesion6.2−5.8 to−16.7 to 23.20.732.9−25.1 to 31.00.821.3−23.0 to 25.50.91
Baseline extension deficit−1.4−13.2 to 10.30.792.9−16.8 to 22.60.764.5−22.5 to 31.50.72−1.2−25.2 to 22.90.92
Graft/contralateral ACL rupture−33.7−52.5 to −14.90.002−29.1−60.6 to 2.40.07−71.0−114.3 to −27.70.004−67.4−105.7 to −29.20.002
1 non-ACL surgery*−4.3−16.3 to 7.80.45−5.4−25.5 to 14.70.57−14.2−42.3 to 13.90.29−7.1−31.5 to 17.40.54
≥2 non-ACL surgeries*6.2−10.1 to 22.50.426.2−20.9 to 33.20.630.2−40.0 to 40.40.997.6−24.8 to 40.00.62
SF-36 MCS at baseline−0.2−0.4 to 0.10.17−0.2−0.7 to 0.20.23−0.2−0.8 to 0.40.56−0.4−0.9 to 0.20.16
KOOS4 baseline−0.2−0.7 to 0.30.350.1−0.6 to 0.90.70−0.3−1.3 to 0.80.60−0.4−1.3 to 0.60.39
Rehabilitation visits−0.1−0.3 to 0.00.12−0.1−0.3 to 0.20.48−0.1−0.4 to 0.30.74−0.1−0.4 to 0.20.53
  • *No non-ACL surgeries was used as a reference category in multivariable analysis.

  • Effect (regression coefficient): the estimate of the average change in a KOOS subscale (scores range from 0 (worst) to 100 (best)) that corresponds to a 1-unit change in the prognostic factor (1-unit=1 point on a 0–100 scale for KOOS4 and SF-36 MCS). All estimates are adjusted for sex, age, smoking, education level and preinjury activity level. Crude unadjusted estimates are presented in see online supplementary appendix. Non-ACL surgery: total number of knee surgery events not performed in the same surgical session as ACL reconstruction or revision. KOOS and SF-36 scores range from 0 (worst) to 100 (best).

  • Statistically significant effects (p<0.05) are highlighted in bold.

  • KOOS4, a mean score from four Knee injury and Osteoarthritis Outcome Score subscales (pain, symptoms, sport/rec and QOL); MCS, Mental Component Score; SF-36, 36-item Short-Form.