Prevalence of osteoporosis and osteopenia at the lumbar spine as measured by dual energy x ray absorptiometry in patients with anorexia nervosa
| Reference | Population studied (age as mean (SD)) | Number of subjects studied | Prevalence of either osteoporosis or osteopenia | Mean T score (lumbar spine unless stated) |
|---|---|---|---|---|
| A T score between −1.0 and −2.5 represents osteopenia. | ||||
| *Two of these three subjects were aged 12 and arguably still gaining bone, so this may represent an overestimate of osteoporosis. | ||||
| †Different data in abstract (42%) and results sections (50%) for AP lumbar spine by dual energy x ray absorptiometry. | ||||
| Grinspoon et al11 | Women with anorexia nervosa aged 24.4 (5.7) | 130 | 13% osteoporosis | −1.4 (mild osteopenia) |
| 50% osteopenia | ||||
| Young et al33 | Anorexia nervosa patients aged 18.1 (0.17) | 18 | 6% osteoporosis (1 subject) | −1.0 (mild osteopenia/borderline normal) |
| 39% osteopenia | ||||
| Bachrach et al41 | Anorexia nervosa patients aged 15.9 (1.5). | 18 | 17% osteoporosis* | −1.5 (osteopenia) |
| 66% had BMD <−2. | ||||
| 56% osteopenia | ||||
| Seeman et al42 | Patients with anorexia nervosa aged 21 years (range 12–40) | 210 | Not given | −1.2 and −1.0 at the femoral neck |
| Seeman et al43 | Patients with anorexia nervosa and secondary amenorrhoea aged 24.4 (8.4) | 37 | Not given | −1.5 (osteopenia) |
| Grinspoon et al22 | Adolescents with anorexia nervosa and | 19 | <21% with osteoporosis | −1.0 (mild osteopenia, borderline normal) |
| secondary amenorrhoea aged 16.0 (1.7) | 50% osteopenia† | |||