Glycogen synthase and glycogen phosphorylase activity in soleus muscle
| Glycogen synthase | Glycogen phosphorylase | |||||
|---|---|---|---|---|---|---|
| Group | GSi+d | GSi | GSi % of total activity | GPa+b | GPa | GPa % of total activity |
| Values are mean (SD) and are expressed as μmol/min per g wet weight and as % of the total activity. | ||||||
| *p<0.05 sedentary v testosterone; †p<0.05 sedentary v hyperglycaemic; ‡p<0.05 hyperglycaemic v hyperglycaemic + testosterone; §p<0.05 hyperglycaemic v hyperglycaemic + trained; ¶p<0.05 hyperglycaemic + trained v hyperglycaemic + trained + testosterone; **p<0.05 hyperglycaemic + exercised v hyperglycaemic + exercised + testosterone. | ||||||
| GSi, active portion of glycogen synthase; GSi+d, total glycogen synthase; GPa, active form of glycogen phosphorylase; GPa+b, total phosphorylase activity. | ||||||
| Sedentary | 4.34 (0.3) | 1.38 (0.2) | 31.9 (4.3) | 16.9 (1.7) | 1.12 (0.1) | 6.8 (0.4) |
| Testosterone | 4.84 (0.3) | 1.84 (0.2)* | 37.8 (3.1)* | 17.0 (4.4) | 0.94 (0.2)* | 6.0 (2.20 |
| Hyperglycaemic | 1.51 (0.1)† | 0.69 (0.2)† | 45.6 (10.5)† | 14.2 (1.9) | 1.52 (0.3)† | 10.7 (1.8)† |
| Hyperglycaemic + testosterone | 2.18 (0.2)‡ | 0.85 (0.1)‡ | 39.5 (8.4) | 11.2 (1.7) | 0.89 (0.2)‡ | 7.9 (2.5) |
| Hyperglycaemic + trained | 1.86 (0.1)§ | 1.11 (0.1)§ | 59.7 (6.1)§ | 17.4 (1.2) | 1.74 (0.4) | 9.9 (2.0) |
| Hyperglycaemic + trained + testosterone | 2.21 (0.2)¶ | 1.25 (0.2)¶ | 57.0 (9.7) | 13.3 (1.2)¶ | 1.40 (0.1) | 10.6 (0.6) |
| Hyperglycaemic + exercised | 1.35 (0.1) | 0.65 (0.1) | 48.2 (10.0) | 25.1 (7.8) | 2.23 (0.6) | 8.9 (0.7) |
| Hyperglycaemic + exercised + testosterone | 1.75 (0.2)** | 0.76 (0.1)** | 43.7 ( 6.5) | 15.6 (3.3)** | 0.84 (0.3)** | 5.5 (1.8)** |