Tenderness values (kp/cm2) and area under the curve (AUC) over 3 and 7 days (kp h/cm2) at the injured site (intention to treat)
| Visit | Day | Diclofenac patch (n = 60) | Placebo patch (n = 60) | |
|---|---|---|---|---|
| *Baseline; †p<0.0001 (diclofenac v placebo); treatment effect +64.7 (95% confidence interval, +48.7 to +80.9 [Hodges–Lehmann estimator]); ‡p<0.0001 (diclofenac v placebo); treatment effect +202.6 (95% confidence interval, +147.3 to +259.1 [Hodges–Lehmann estimator]). | ||||
| AUC0–3d, AUC over 3 days; AUC0–7d, AUC over 7 days; Q1, lower quartile; Q3, upper quartile; SD, standard deviation. | ||||
| 1* | 1 | Mean (median) | 1.5 (1.3) | 1.4 (1.3) |
| SD | 0.77 | 0.67 | ||
| Q1; Q3 | 1.0; 2.0 | 0.9; 1.8 | ||
| 2 | 1 | Mean (median) | 2.7 (2.7) | 1.6 (1.6) |
| SD | 1.22 | 0.71 | ||
| Q1; Q3 | 1.9; 3.8 | 1.0; 2.0 | ||
| 3 | 2 | Mean (median) | 3.4 (3.2) | 1.9 (1.7) |
| SD | 1.12 | 0.83 | ||
| Q1; Q3 | 2.6; 4.1 | 1.2; 2.4 | ||
| 4 | 2 | Mean (median) | 3.9 (3.8) | 2.1 (1.9) |
| SD | 1.24 | 0.83 | ||
| Q1; Q3 | 3.0; 4.5 | 1.5; 2.8 | ||
| 5 | 3 | Mean (median) | 4.3 (4.0) | 2.5 (2.3) |
| SD | 1.27 | 0.85 | ||
| Q1; Q3 | 3.3; 5.1 | 2.0; 2.9 | ||
| 6 | 3 | Mean (median) | 4.5 (4.2) | 2.7 (2.8) |
| SD | 1.26 | 0.89 | ||
| Q1; Q3 | 3.5; 5.5 | 2.0; 3.3 | ||
| 7 | 7 | Mean (median) | 4.9 (4.6) | 3.5 (3.4) |
| SD | 1.29 | 0.91 | ||
| Q1; Q3 | 3.9; 6.0 | 3.0; 4.1 | ||
| AUC0–3d | Mean (median) | 162.4† (153.1) | 93.7 (86.8) | |
| SD | 52.57 | 35.59 | ||
| Q1; Q3 | 120.4; 198.4 | 68.3; 118.4 | ||
| AUC0–7d | Mean (median) | 613.8‡ (572.2) | 394.0 (369.1) | |
| SD | 171.15 | 116.20 | ||
| Q1; Q3 | 469.3; 742.6 | 319.5; 487.8 | ||