Genes upregulated or downregulated in cultured tendon cells following exposure to nitric oxide15
| Primary function | Gene | Effect on gene regulation |
|---|---|---|
| COP, coat protein complex; GTPase, guanosine triphosphatase; IGF, insulin-like growth factor; MET, methionine; PRKA, protein kinase A-anchoring; SMA, smooth muscle actin; TGF, transforming growth factor; TNF, tumour necrosis factor. | ||
| Apoptosis | Immediate early response 3 | Up |
| Jun D | Up | |
| COP9 constitutive photomorphogenic homologue subunit 8 | Up | |
| Growth arrest-specific 2 like 1 | Down | |
| Cell adhesion/communication | Protocadherin α6 | Up |
| Catenin (cadherin-associated protein), δ2 | Down | |
| Cell cycle control | Cell division cycle 34 | Down |
| Cell growth and/or maintenance | Potassium inwardly rectifying channel, subfamily J, member 8 | Up |
| Translocated promoter region (to activated MET) | Up | |
| Human cellular proto-oncogene (c-mer) | Down | |
| TGF-β inducible early protein | Down | |
| S100 calcium-binding protein A11 | Up | |
| Extracellular matrix/regulation | Matrix metalloproteinase 10 (stromelysin 2) | Down |
| Collagen type I, α1 | Down | |
| Decorin | Down | |
| Laminin B2 | Down | |
| Biglycan | Down | |
| Collagen type III, α1 | Down | |
| Collagen type IV, α5 | Up | |
| Microfibrillar-associated protein 3-like | Up | |
| Oxidative stress resistance | Oxidation resistance 1 | Up |
| Signal transduction | TNF receptor-associated factor 5 | Up |
| Rho GTPase-activating protein 4 | Up | |
| Interleukin 18 receptor 1 | Up | |
| IGF-II mRNA-binding protein 3 | Up | |
| SMA D5 | Up | |
| Phospholipase D1, phophatidylcholine-specific | Up | |
| Tyrosine 3-mono-oxygenase/tryptophan 5-mono-oxygenase activation protein, ζpolypeptide | Up | |
| Ras suppressor protein 1 | Up | |
| Interferon regulatory factor 3 | Up | |
| A kinase (PRKA) anchor protein 10 | Up | |
| Mitogen-activated protein kinase 7 | Down | |
| Transport, cell growth and/or maintenance | Solute carrier family 22 | Up |