Author | Was the spectrum of patients representative of the patients who will receive the test in practice? | Were selection criteria clearly described? | Was the reference standard likely to correctly classify the target condition? | Was the time period between reference standard and index test short enough to be reasonably sure that the target condition did not change between the two sets? | Did the whole sample or a random selection of the sample receive verification using a reference standard of diagnosis? | Did the patients receive the same reference standard regardless of the index test result? | Was the reference standard independent of the index test? (ie the index test did not form part of the reference standard) | Was the execution of the index test described in sufficient detail to permit its replication? | Was the execution of the reference test described in sufficient detail to permit its replication? | Were the index test results interpreted without knowledge of the results of the reference standard? | Were the reference standard results interpreted without knowledge of the results of the index test? | Were the same clinical data available when test results were interpreted as would be available when the test is used in practice? | Were un-interpretable /intermediate test results reported? | Were withdrawals from the study explained? |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | |
Beumer et al 26 | No | No | Yes | Yes | No | No | N/A | Yes | Unclear | Yes | Unclear | Yes | Yes | Yes |
Nussbaum et al16 | Yes | Yes | No | Yes | Yes | Yes | N/A | Yes | Yes | Unclear | Unclear | Yes | Yes | Yes |
Alonsoet al36 * | Yes | Yes | N/A | N/A | N/A | N/A | N/A | Yes | N/A | N/A | N/A | Yes | Yes | Yes |
*QUADAS tool appropriate for reliability, not for validity. Therefore no reference test was required (items 3–7, 9–11).
N/A, the item is not applicable to this study.