Mean and 95% CI of secondary outcomes including the adjusted mean difference between groups
| Outcome | Patient education (n=59) | Patient education and exercise therapy (n=62) | Adjusted mean difference between groups (95% CI) |
|---|---|---|---|
| Worst pain last week (mm) (months) | |||
| 3 | 51 (44;58) | 40 (24;56) | −11 (−30 to 9) |
| 6 | 51 (31;70) | 41 (21;60) | −10 (−38 to 19) |
| 12 | 49 (45;53) | 37 (34;39) | −11 (−18 to 5) |
| 24 | 35 (1;69) | 24 (15;33) | −11 (−46 to 25) |
| KOOSpain (0–100, worst to best) (months) | |||
| 3 | 71 (67;74) | 78 (76;81) | 4 (−2 to 11) |
| 6 | 74 (74;75) | 79 (76;82) | 2 (−6 to 9) |
| 12 | 73 (70;76) | 79 (79;80) | 3 (0 to 6)* |
| 24 | 73 (61;84) | 85 (84;85) | 10 (3 to 17)* |
| KOOSsymptoms (0–100, worst to best) (months) | |||
| 3 | 79 (75;80) | 84 (82;86) | 3 (2 to 4)* |
| 6 | 80 (73;85) | 82 (74;89) | 0 (−9 to 9) |
| 12 | 77 (77;78) | 83 (81;85) | 2 (−2 to 5) |
| 24 | 76 (67;86) | 84 (81;87) | 7 (−4 to 19) |
| KOOSADL (0–100, worst to best) (months) | |||
| 3 | 81 (79;82) | 89 (89;89) | 5 (−1 to 11) |
| 6 | 84 (83;85) | 90 (87;92) | 3 (−3 to 9) |
| 12 | 83 (82;83) | 89 (88;90) | 3 (0 to 6)* |
| 24 | 83 (75;91) | 91 (90;92) | 6 (1 to 12)* |
| KOOSsport/rec (0–100, worst to best) (months) | |||
| 3 | 58 (53;62) | 68 (64;73) | 6 (−4 to 16) |
| 6 | 61 (60;61) | 71 (60;82) | 5 (−13 to 22) |
| 12 | 58 (51;65) | 70 (64;77) | 7 (−7 to 20) |
| 24 | 62 (43;80) | 75 (68;82) | 10 (−7 to 28) |
| KOOSQOL (0–100, worst to best) | |||
| 3 | 54 (52;57) | 62 (54;71) | 6 (−5 to 16) |
| 6 | 58 (56;59) | 63 (52;75) | 4 (−9 to 18) |
| 12 | 59 (59;60) | 65 (63;67) | 4 (1 to 6)* |
| 24 | 58 (47;69) | 71 (65;78) | 12 (0 to 25)* |
| Sport sessions per week† (times per week) (months) | |||
| 3 | 1 (0;2.5) | 1 (0;3) | 0.07 (−0.19 to 0.34)‡ |
| 6 | 2 (0;3) | 1 (0;2.5) | −0.19 (−0.44 to 0.06)‡ |
| 12 | 2 (0;3) | 1.5 (0;3) | −0.11 (−0.63 to 0.41)‡ |
| 24 | 1 (0–2) | 1.5 (0;2.5) | 0.31 (−0.19 to 0.81)‡ |
| PAS† (metabolic equivalent) (months) | |||
| 3 | 46.4 (45.7;47.0) | 44.6 (42.2;47.1) | −1.8 (−3.7 to 0.2) |
| 6 | 47.5 (41.3;53.7) | 45.6 (44.9;46.4) | −2.4 (−7.0 to 2.1) |
| 12 | 47.6 (44.6;50.6) | 47.9 (45.3;50.4) | 0.0 (−4.3 to 4.2) |
| 24 | 47.6 (43.7;52.7) | 46.3 (37.2;51.4) | −2.5 (−6.3 to 1.3) |
| EQ-5D† (index score) (months) | |||
| 3 | 0.78 (0.72;0.82) | 0.78 (0.78;1.00) | 0.04 (−0.03 to 0.12)‡ |
| 6 | 0.76 (0.66;0.82) | 0.82 (0.72;0.84) | 0.00 (−0.12 to 0.12)‡ |
| 12 | 0.78 (0.72;0.82) | 0.82 (0.77;1.00) | 0.03 (−0.09 to 0.14)‡ |
| 24 | 0.82 (0.72;0.84) | 0.82 (0.78;1.00) | 0.05 (−0.01 to 0.11)‡ |
*<0.05.
†Median and IQR.
‡Coefficients from Poisson regression. The value is the expected increase in log count for the group randomised to exercise therapy and patient education compared to the group randomised to patient education alone.
EQ-5D, EuroQol 5-dimensions; KOOS, Knee injury and Osteoarthritis Outcome Score; PAS, Physical Activity Scale.