Overview of outcome measures per study
| Study type | Intervention/comparison | OMERACT III set of outcome measures | ||||||
|---|---|---|---|---|---|---|---|---|
| Pain | Function | Global assessment | Joint imaging | |||||
| VAS/NRS | WOMAC pain | WOMAC physical function | WOMAC total | Lequesne index | Patient satisfaction | Scoring radiographs or demonstrably superior imaging techniques | ||
| RCTs | PRP-placebo | √1 | √1* | √1* | √1* | – | √1 | – |
| PRP-HA | √2, 3 | √2, 3 | √2, 3, 4, 5 | √2, 3, 5 | √6* | – | ||
| CCTs | PRP-HA | √7, 8 | – | – | √8 | – | √7,*9 | – |
| CCTs | PRP-PRGF | – | – | – | – | – | √10 | – |
1, Patel et al;37 2, Sánchez et al;40 3, Vaquerizo et al;36 4, Cerza et al;39 5, Li et al;43 6, Filardo et al;38 ,44 8, Spaková et al;42 9, Kon et al;16 ,45 10, Filardo et al.23
*Outcome measure not applicable or not reported in the included study.
−, No primary or secondary outcome measure in included study; √, study on outcome measure; CCT, non-randomised controlled trial; HA, hyaluronic acid; NRS, numeric rating scale; PRGF, plasma rich in growth factors; PRP, platelet-rich plasma; RCT, randomised controlled trial; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.