Table 3

Overview of intervention effect per study in time

Study	Outcome	Subgroup	3 months postinjection	6 months postinjection	12 months postinjection
Vaquerizo et al36	Pain	Percentage of patients having a 50% decrease in the WOMAC pain subscale		+	+
	Function	Percentage of patients having a 50% decrease in the WOMAC physical function subscale		+	+
		Percentage of patients having a 50% decrease in the Lequesne index		+	+
		WOMAC total score		+	+
		Lequesne index		+	+
Cerza et al39	Function	WOMAC total score	+	+
Sánchez et al40	Pain	Percentage of patients having a 50% decrease in the WOMAC pain subscale		+
		WOMAC pain subscale		−
	Function	WOMAC physical function subscale		−
		WOMAC total score		−
		Lequesne index		−
Li et al43	Function	WOMAC total score	−	+
		Lequesne index	−	+
Spaková et al42	Pain	NRS	+	+
	Function	WOMAC total score	+	+
Say et al41	Pain	VAS	+	+

+, indicates positive effect derived from the p value (p value <0.05);
−, indicates negative effect derived from the p value (p value >0.05);
NRS, numeric rating scale; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.