(A) Randomised, controlled trials (overwhelming data) | Provides a consistent pattern of findings with substantial studies |
(B) Randomised, controlled trials (limited data) and high-quality observational data | Few randomised trials exist which are small in size, and results are inconsistent or observation studies supported by evidence of causality from acute or experimental studies |
(C) Non-randomised trials, observational studies | Outcomes are from uncontrolled, non-randomised, and/or observational studies |
(D) Panel consensus judgement | Panel’s expert opinion when the evidence is insufficient to place it in categories A–C |