Displaying 1-9 letters out of 265 published
Angiogenesis towards Adipogenesis: Role of vascular endothelial growth factor
We have read the respective article and we agreed with all great findings. But just need to emphasized on some thing very important and crucial. We are working with adipocytes and adipose tissue is capable of expanding many-fold during adulthood, therefore requiring the formation of new vasculature to supply growing and proliferating adipocytes. The expansion of the vasculature in adipose tissue occurs through angiogenesis, where new blood vessels develop from those pre-existing within the tissue (Corvera et al., 2013). Previous studies indicated that adipogenesis may be regulated by factors that drive angiogenesis. Fundamental aspects of angiogenesis, including basement membrane breakdown, vasculogenesis, angiogenic remodeling, vessel stabilization, and vascular permeability. Critical angiogenic factors include vascular endothelial growth factor (VEGF), VEGF receptors, angiopoietins (Ang), ephrins, matrix metalloproteinases, and the plasminogen enzymatic system. Vascular endothelial growth factor is the most critical factor because it initiates the formation of immature vessels and disruption of a single VEGF allele leads to embryonic lethality in mice. Expression of VEGF is influenced by hypoxia, insulin, growth factors, and several cytokines (Hausman et al., 2004). The VEGF has been reported to be modulated by leptin and hCG (Islami et al., 2003) and more recently the expression of angiogenic regulators, VGEF and leptin has been reported to be regulated by the EGF/PI3K/STAT3 pathway (Cascio et al., 2009). These vital findings reflects a regulation of secondary diseases related to obesity to be the result of complex molecular events and adipose tissue vasculature as a source of new targets for metabolic disease therapies. This gene is located on chromosome 11q13 (7 exons). VEGFB has been reported to have a role in endothelial targeting of lipids to peripheral tissues. Dietary lipids present in circulation must be transported through the vascular endothelium to be metabolized by tissue cells. Bioinformatic analysis showed that VEGFB was tightly coexpressed with nuclear-encoded mitochondrial genes across a large variety of physiologic conditions in mice, pointing to a role for VEGFB in metabolism. VEGF specifically controlled endothelial uptake of fatty acids via transcriptional regulation of vascular fatty acid transport proteins. As a consequence, Vegfb-/- mice showed less uptake and accumulation of lipids in muscle, heart, and brown adipose tissue, and instead shunted lipids to white adipose tissue. The co-expression of VEGFB and mitochondrial proteins introduces a novel regulatory mechanism, whereby endothelial lipid uptake and mitochondrial lipid use are tightly coordinated (Hagberg et al., 2012). In our study, we are also looking in to identify the mutation(s) in the VEGF-B gene in Malayisan Obese attributes towards CHD risk. We hypothesized, if there is a mutation in VGEF-B, then the obese subject will be predicted to have hypertension and if there will be no mutation then signs of metabolic syndrome and diabetes type II will be predicted in obese attribute in future. Most important the role of VEGF as major autocrine mediator of FGF-2-induced angiogenesis and proliferation (Naim et al 2005) should be considered by respective researchers in future.
Cascio S, Ferla R, D'Andrea A, Gerbino A, Bazan V, Surmacz E, Russo A. Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells. J Cell Physiol. 2009 Oct;221(1):189-94. doi: 10.1002/jcp.21843.
Corvera S, Gealekman O. Adipose tissue angiogenesis: Impact on obesity and type-2 diabetes. Biochim Biophys Acta. 2013 Jun 12. doi:pii: S0925-4439(13)00211-1. 10.1016/j.bbadis.2013.06.003.
Hagberg CE, Mehlem A, Falkevall A, Muhl L, Fam BC, Orts?ter H, Scotney P, Nyqvist D, Sam?n E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sj?holm A, Nash A, Eriksson U. Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes. Nature. 2012 Oct 18;490(7420)
Islami D, Bischof P, Chardonnens D. Modulation of placental vascular endothelial growth factor by leptin and hCG. Mol Hum Reprod. 2003 Jul;9(7):395-8.
Naim R, Chang RC, Sadick H, Bayerl C, Bran G, Hormann K. Effect of vascular endothelial growth factor on fibroblasts from external auditory canal cholesteatoma. Arch Med Res. 2005 Sep-Oct;36(5):518-23. PubMed PMID: 16099332.
Conflict of Interest:
Fundamentally important information
Having taught medical students about the benefits of PA for the past 20 years and lived through WHO's 2002 World health day on PA, I had the belief that PA was now integrated and implemented in everyday practice. This nice little piece of research reminds us how difficult it is to change "routine" and how uncomfortable some of us feel when encouraging people to change their behaviour. Back to the drawing board...
Conflict of Interest:
Endurane Running and nutrition
The article suggests that using fat as an energy source is how to fuel endurance events.
Why is it that top marathons runners and the SKY/GB team don't do this but have a good balance of mainly carbohydrate and protein?
Because using fat requires 3% more oxygen for the same amount of energy. Thus energy release is slower and it is why top athletes train specifically to perform glycogen depleted. If you understand the physiology it is so wrong. Why do cyclists consume carbohydrate during long stages
Conflict of Interest:
Can evolution explain the jumper's knee paradox?
I read the excellent study by Halland et al with great interest (1). This study adds further support to the link between higher jumping performance and the development of patellar tendinopathy, as the authors note in the discussion (2). The reasons for this link are unclear but it is worth considering evolutionary theory in any explanation. The 'pleiotropy' theory for the evolution of ageing proposes that there are genetically determined 'trade-offs' between benefits to younger organisms and their viability at older ages (3, 4). In this way the advantage conferred by better jumping performance at a young age may be part of the same genetic package that results in the disadvantage of an increased susceptibility to tendinopathy at an older age.
1. Helland C, Bojsen-Moller J, Raastad T, Seynnes OR, Moltubakk MM, Jakobsen V, et al. Mechanical properties of the patellar tendon in elite volleyball players with and without patellar tendinopathy. British journal of sports medicine. 2013. Epub 2013/07/09. 2. Visnes H, Aandahl HA, Bahr R. Jumper's knee paradox--jumping ability is a risk factor for developing jumper's knee: a 5-year prospective study. British journal of sports medicine. 2013;47(8):503-7. Epub 2012/10/13. 3. Kirkwood TB. Evolution of ageing. Mechanisms of ageing and development. 2002;123(7):737-45. Epub 2002/03/01. 4. Partridge L, Gems D. Mechanisms of ageing: public or private? Nature reviews Genetics. 2002;3(3):165-75. Epub 2002/04/25.
Conflict of Interest:
"Role of Micronutrients, Antioxidants, Vitamin D and Virgin Olive Oil in Promoting Oral Health"
Dear Sir, We have read the nice article "Oral health and impact on performance of athletes participating in the London 2012 Olympic Games: a cross-sectional study" by Dr. Needleman and colleagues in your journal (Br J Sports Med2013;47: 1054-1058)(1). In developing countries, the prevalence of dental and periodontal diseases is very high as people have lack of knowledge and are ignorant about oral health(2). Even though the athletes are having physical fitness they might not have given importance for oral health. Food and liquids should be kept in the mouth for a very brief period (3). Food particles continue to remain in the mouth after food and liquid intake because sensory adaptation of the mouth for these particles is very rapid. Lack of antioxidants and micronutrients increases the incidence of dental and periodontal diseases. During high stress periods, intake of micronutrients and antioxidants results in decreased inflammatory processes. High stress exposure is one of the possible factors for exerting an unfavorable influence on periodontal health such as plaque accumulation, local gingivitis and a change in salivary composition (4). In developing countries, the prevalence of vitamin D deficiency ranges between 30-90% (5). Vitamin D acts as an anti- inflammatory agent and stimulates the production of anti-microbial peptides in the saliva (6). Use of 1-2 ml of virgin olive oil (rich in Oleic acid and Phenolic antioxidants)after brushing in the morning and at night before going to sleep will be of help in removing residual food particles and decreasing bacterial growth and adhesion in oral cavity (7, 8).
1. Needleman I, Ashley P, Petrie A, Fortune F et al. Oral health and impact on performance of athletes participating in the London 2012 Olympic Games: a cross-sectional study Br J Sports Med 2013;47:1054-1058
2. Petersen PE, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C. The global burden of oral diseases and risks to oral health. Bull World Health Organ. 2005; 83(9):661-9.
3. Dawes C Salivary flow patterns and the health of hard and soft oral tissues. JADA 2008; 139(5 supp); 18S-24S. 4. Willershausen B, Ross A, F?rsch M, Willershausen I, Mohaupt P, Callaway A. The influence of micronutrients on oral and general health Eur J Med Res. 2011; 16(11): 514-518 5. Arabi A, El Rassi R, El-Hajj Fuleihan G. Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol. 2010;6(10):550-61
6. Stein SH, Tipton DA; Vitamin D and its impact on oral health--an update. [Journal Article, Review]; J Tenn Dent Assoc 2011; 91(2):30-33.
7. Pretty IA, Gallagher MJ, Martin MV, Edgar WM, Higham SMA study to assess the effects of a new detergent-free, olive oil formulation dentifrice in vitro and in vivo. Dent. 2003 Jul;31(5):327-32
8. Math M.V. Olive Oil and Water - Role in Oral Care. International Journal of Medical and Clinical Research 2013; 4 (1); 258-260.
Dr Mahantayya V Math Dr Yashoda R kattimani Dr Rita M khadkikar MGM Medical College Kamothe, Navi Mumbai Maharashtra state, India
Conflict of Interest:
Combined exercise and mobilisation techniques beneficial in treating lateral epicondylalgia
As a topic worthy of updating, it is disappointing to note fundamental issues with both the methodology of this review as well as errors in reporting of studies, leading to a limited perspective of the role of exercise therapy and mobilisation techniques in treatment of epicondylalgia. There are two major issues that readers ought to be made aware of regarding this review.
Issue 1: A major issue is the lack of a comprehensive search strategy, with a simple pubmed search identifying several studies (Smidt et al., 2002; Bisset et al., 2006; Croisier et al., 2007 ; Luginbuhl et al., 2008; Nagrale et al., 2009) and at least two other systematic reviews (Bisset et al., 2005; Herd et al., 2008) published within the author specified census period. Stark omissions are two randomised trials, which followed 185 (Smidt et al., 2002) and 198 (Bisset et al., 2006) participants over one year. At least nine additional studies (Park et al., 2010; Slater et al., 2010; Tyler et al., 2010; Peterson et al., 2011; Wen et al., 2011; Fernandez-Carnero et al., 2012; Soderberg et al., 2012; Viswas et al., 2012; Coombes et al., 2013) and a systematic review (Raman et al., 2012) could be found beyond the census period, indicating that an update is already timely.
The most noticeable gap in the literature presented by Hoogvliet, is that in which exercise and manipulative treatments are included as a part of a multimodal therapy program. Amongst missing evidence in this review, is that which favours, in terms of speeding up resolution, the use of a multimodal program including elbow mobilisation and concentric and eccentric exercise compared to wait and see (Bisset et al., 2006) or placebo intervention (Coombes et al., 2013). Given that combining exercise and manual therapy reflects much of what occurs in clinical practice, its absence is concerning.
Issue 2: There are errors in presentation of data from individual studies. Readers might be better advised to refer to individual papers, however, this in itself may be problematic given some studies were not correctly referenced to the intended trials (e.g., #30(Cleland et al., 2005), #11(Fernandez-Carnero et al., 2008)). That is, the study by Cleland should refer to the pilot study of 10 participants (Cleland et al., 2005), not the retrospective analysis of 112. There is misrepresentation of studies, for example patient numbers, study design and results are ether incorrect, incomplete or missing for #24 (Vicenzino et al., 1996) variably so in Appendix 1 and text.
Bisset, L., Beller, E., Jull, G., Brooks, P., Darnell, R. & Vicenzino, B. (2006) Mobilisation with movement and exercise, corticosteroid injection, or wait and see for tennis elbow: randomised trial. BMJ 333, 939.
Bisset, L., Paungmali, A., Vicenzino, B. & Beller, E. (2005) A systematic review and meta-analysis of clinical trials on physical interventions for lateral epicondylalgia. Br J Sports Med 39, 411-422; discussion 411-422.
Cleland, J., Flynn, T.W. & Palmer, J.A. (2005) Incorporation of manual therapy directed at the cerviothoracic spine in patients with lateral epicondylalgia. A pilot clinical trial. J Man Manip Ther 13, 143- 151.
Coombes, B.K., Bisset, L., Brooks, P., Khan, A. & Vicenzino, B. (2013) Effect of corticosteroid injection, physiotherapy or both on clinical outcomes in patients with unilateral lateral epicondylalgia. A randomized controlled trial. JAMA 309, 461-469.
Croisier, J.L., Foidart-Dessalle, M., Tinant, F., Crielaard, J.M. & Forthomme, B. (2007) An isokinetic eccentric programme for the management of chronic lateral epicondylar tendinopathy. Br J Sports Med 41, 269-275.
Fernandez-Carnero, J., Cleland, J.A. & Arbizu, R.L. (2012) Examination of motor and hypoalgesic effects of cervical vs thoracic spine manipulation in patients with lateral epicondylalgia: a clinical trial. J Manipulative Physiol Ther 34, 432-440.
Fernandez-Carnero, J., Fernandez-de-las-Penas, C. & Cleland, J.A. (2008) Immediate hypoalgesic and motor effects after a single cervical spine manipulation in subjects with lateral epicondylalgia. J Manipulative Physiol Ther 31, 675-681.
Herd, C.R. & Meserve, B.B. (2008) A systematic review of the effectiveness of manipulative therapy in treating lateral epicondylalgia. J Man Manip Ther 16, 225-237.
Luginbuhl, R., Brunner, F. & Schneeberger, A.G. (2008) No effect of forearm band and extensor strengthening exercises for the treatment of tennis elbow: a prospective randomised study. La Chirurgia degli organi di movimento 91, 35-40.
Nagrale, A.V., Herd, C.R., Ganvir, S. & Ramteke, G. (2009) Cyriax physiotherapy versus phonophoresis with supervised exercise in subjects with lateral epicondylalgia: a randomized clinical trial. J Man Manip Ther 17, 171-178.
Park, J.Y., Park, H.K., Choi, J.H., Moon, E.S., Kim, B.S., Kim, W.S. & Oh, K.S. (2010) Prospective evaluation of the effectiveness of a home-based program of isometric strengthening exercises: 12-month follow- up. Clinics in orthopedic surgery 2, 173-178.
Peterson, M., Butler, S., Eriksson, M. & Svardsudd, K. (2011) A randomized controlled trial of exercise versus wait-list in chronic tennis elbow (lateral epicondylosis). Upsala journal of medical sciences 116, 269 -279.
Raman, J., Macdermid, J.C. & Grewal, R. (2012) Effectiveness of different methods of resistane exercses in lateral epicondylosis - a systematic review. J Hand Ther 25, 5-25.
Slater, H., Theriault, E., Ronningen, B.O., Clark, R. & Nosaka, K. (2010) Exercise-induced mechanical hypoalgesia in musculotendinous tissues of the lateral elbow. Man Ther 15, 66-73.
Smidt, N., van der Windt, D.A., Assendelft, W.J., Deville, W.L., Korthals-de Bos, I.B. & Bouter, L.M. (2002) Corticosteroid injections, physiotherapy, or a wait-and-see policy for lateral epicondylitis: a randomised controlled trial. Lancet 359, 657-662.
Soderberg, J., Grooten, W.J. & Ang, B.O. (2012) Effects of eccentric training on hand strength in subjects with lateral epicondylalgia: a randomized-controlled trial. Scand J Med Sci Sports 22, 797-803.
Tyler, T.F., Thomas, G.C., Nicholas, S.J. & McHugh, M.P. (2010) Addition of isolated wrist extensor eccentric exercise to standard treatment for chronic lateral epicondylosis: a prospective randomized trial. J Shoulder Elbow Surg 19, 917-922.
Vicenzino, B., Collins, D. & Wright, A. (1996) The initial effects of a cervical spine manipulative physiotherapy treatment on the pain and dysfunction of lateral epicondylalgia. Pain 68, 69-74.
Viswas, R., Ramachandran, R. & Korde Anantkumar, P. (2012) Comparison of effectiveness of supervised exercise program and Cyriax physiotherapy in patients with tennis elbow (lateral epicondylitis): a randomized clinical trial. TheScientificWorldJournal 2012, 939645.
Wen, D.Y., Schultz, B.J., Schaal, B., Graham, S.T. & Kim, B.S. (2011) Eccentric strengthening for chronic lateral epicondylosis: a prospective randomized study. Sports health 3, 500-503.
Conflict of Interest:
Judo, the way of mutual welfare and benefits
I would like to congratulate Dr. Nikos Malliaropoulos for the initiative to organize a Judo and Martial Arts issue in this prestigious journal1, a topic with increased number of publications in the last decades.2 However, despite the broad range of topics suggested in the initial call for papers1, only four papers (including the editorial) about judo/martial arts were published, which can be an indicative that the high -level quality required by the British Journal of Sporst Medicine is still to be achieved by researchers working on this topic, although no information was provided in the editorial concerning the number of papers submitted and the proportion of articles approved. Other aspects in this editorial also deserve attention: (a) despite the fact that the Kodokan Judo Institute 3 and the International Judo Federation4 present the date of judo creation as 1882, the authors presented 1888 as the year judo was invented, but no reference was given for this fact; (b) the affirmation that "very little has changed since judo was invented.."(p.1137)5 is greatly different from what researchers in judo history6 and sport sociology7 have presented, especially about what has been called judo Westernization or reflexive judo institutional modernization7,8 and women participation, mainly in Japan9; (c) it is well known that Dr. Jigoro Kano (the founder of judo) proposed this modality to achieve different groups and to contribute to physical, moral and intelectual development6 and that there is a tendency to believe that martial arts can contribute to children development especifically 10, but the use of the International Judo Federation4 as reference to describe the benefits of judo lacks scientific background. Prudent skepticism was recommended11 and a lack of evidence was presented12 concerning the real effects of martial arts programs on children development. Furthermore, many recent cases of catastrophic head and neck injuries13, and of female Japanese athletes being physically punished by their coaches, among other problems, have been reported recently in judo.14 Thus, a more balanced and critical view would be preferred in this editorial; (d) although a traditional judo especialization course has been promoted by the International Budo University (Japan) for many years15, and a specialization for judo coaches has been offered by Leipzig University since 199116, the authors of the editorial opted to describe only a course in which one of them is the coordinator and another is a former student, while no competing interests were reported; (e) finally, there is no such institution called "International Judo Federation Union" as presented in the end of the editorial. I hope this letter helps to improve the information provided by the authors and contribute to discussions concerning judo and martial arts research for mutual welfare and benefits as proposed by the founder of judo, Dr. Jigoro Kano. Emerson Franchini Martial Arts and Combat Sports Research Group, School of Physical Education and Sport, University of S?o Paulo, Brazil The author of this letter declare no competing interests.
References 1. Khan, K. Call for papers - the ECOSEP BJSM judo and martial arts issue 2013. http://blogs.bmj.com/bjsm/2013/04/02/call-for-papers-the-ecosep-bjsm -judo-and-martial-arts-issue-2013/ (accessed 19 Nov 2013) 2. Peset F, Ferrer-Sapena A, Villam?n M et al. Scientific literature analysis of judo in Web of Science ?. Arch Budo 2013;9:81-91. 3. History of Kodokan Judo. Kodokan Judo Institute. http://www.kodokan.org/e_basic/history.html (accessed 19 Nov 2013) 4. What is judo? International Judo Federation. http://www.worldjudoday.com/en/WhatisJudo-57.html (accessed 20 Nov 2013) 5. Malliaropoulos, N, Callan M, Puim B. Judo, the gentle way. Br J Sports Med 2013;47:1137. 6. Carr KG. Making way: war, philosophy and sport in Japanese judo. J Sport Hist 1993;20:167-88. 7. Villam?n M, Brown D, Espartero J, Guti?rrez C. Reflexive modernization and the disembedding of judo from 1946 to the 2000 Sydney Olympics. Int Review Sociol Sport 2004;39:139-56. 8. Saeki T. Organizational reformation of the All Japan Judo Federation organization: a sociological study of issues surrounding the conflict between tradition and modernization in a sport. Int Review Sociol Sport 1994;29:301-15. 9. Miarka B, Marques JB, Franchini E. Reinterpreting the history of women's judo in Japan. Int J Hist Sport 2011;28:1016-29. 10. Diamond A, Lee K. Interventions shown to aid executive function development in children 4 to 12 years old. Science 2011;333:959-64. 11. Strayhorn JM, Strayhorn JC. Martial arts research: prudente skepticism. Science 2011;334:310. 12. Mercer J. Martial arts research: weak evidence. 2011;334:310-1. 13. Kamitani T, Nimura Y, Nagahiro S, et al. Catastrophic head and neck injuries in judo players in Japan from 2003 to 2010. Am J Sports Med 2013;41:1915-21. 14. Judo coach's physical assault off emale athletes is a warning to entire Japanese sporting world. http://www.japan- press.co.jp/modules/news/index.php?id=5054 (accessed 20 Nov 2013). 15. International Budo University Special Course - Budo Specialization Program. http://www.budo-u.ac.jp/english/pdf/Information.pdf (accessed 20 Nov 2013). 16. International Coaching Course. http://www.uni- leipzig.de/~itk/itk/html/general_information.html. (accessed 20 Nov 2013).
Conflict of Interest:
Physical activity during pregnancy and the risk of gestational diabetes
My first question would be: what drug company funded this study? How many studies have there been over this last century showing exercise decreases and cures diabetes? Many.
I find this type of "so-called" science incredibly dangerous and irresponsible as many women will make it an excuse to not exercise during pregnancy. Exercise during pregnancy most definitely not only reduces risk of diabetes but i have over the last 20 years with many clients, not only controlled, but some even reversed Gestational diabetes, within 2 weeks. But it takes 5-6 days a week of minimum 45 minutes of decent intensity exercise. And elimination of all white carbohydrates. And with Asian women propensity for Gestational diabetes, which i would attribute to thousands of years of eating white rice, eliminating white carbohydrates should be mandatory for all pregnant women. Exercise does reduce risk of obesity, depression, preeclampsia and premature delivery and most gestational issues, all of which we have an epidemic of in the States. Actually i would call them "In-activity issues" not gestational. What are you thinking?
Conflict of Interest:
One off events are great but they don't deliver change
The research into the physical activity response to the Sydney Olympics (and Paralympics) recognises that without a planned and sustainable investment in physical activity programmes over time there is no evidence of improvement.
This should not surprise us for three reasons:
1. People may be inspired by elite performance and feel the desire to increase their participation but this will not be sufficient to convert that intent into behaviour change
2. Individuals will respond to structured marketing which taps into their personal goal motivations (for example in our research a focus on: making friends, improving health, having fun, improving self image, progressing in life will trigger a positive response from disabled people)
3. There needs to be strategic long term investment in the type of inclusive participation opportunities which are designed to respond to the demands of new participants and not just the needs of existing, committed sports participants. For example Sporting bodies and gyms should consider what their current club offer feels like for someone turning up for the first time
I believe that the early indications are that this approach is being applied effectively in England and the long term prognosis is significantly more optimistic than the Australian experience.
Conflict of Interest:
EFDS is a Charity which is partly funded by Sport England to increase the participation of disabled people in sport.
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