Antioxidant Enzyme Peroxiredoxin 5 Is Upregulated in Degenerative Human Tendon

doi:10.1006/bbrc.2001.4991

Biochemical and Biophysical Research Communications

Volume 284, Issue 3, 15 June 2001, Pages 667-673

https://doi.org/10.1006/bbrc.2001.4991 Get rights and content

Abstract

Peroxiredoxin 5 (PRDX5) is a novel thioredoxin peroxidase recently identified in a variety of human cells and tissues, which is considered to play an important role in oxidative stress protection mechanisms. However, little is known about its expression in tendon degeneration, a common and disabling condition that primarily affects older people, in which oxidative stress may be implicated. The present study demonstrated that normal human tendon expresses PRDX5 and its expression is significantly increased in degenerative tendon. In addition, we have localized PRDX5 to fibroblasts in normal tendon and to both fibroblasts and endothelial cells in degenerate tendon. The differential expression of PRDX5 in normal and degenerate tendon shows that a thioredoxin peroxidase with antioxidant properties is upregulated under pathophysiological conditions and suggests that oxidative stress may be involved in the pathogenesis of tendon degeneration. PRDX5 may play a protective role against oxidative stress during this pathophysiological process.

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Regular ArticleAntioxidant Enzyme Peroxiredoxin 5 Is Upregulated in Degenerative Human Tendon

Abstract

Orthop. Clin. North Am.

Exp. Gerontol.

Curr. Opin. Cell Biol.

Clin. Biochem.

Free Radic. Biol. Med.

Free Radic. Biol. Med.

Pathophysiology

J. Biol. Chem.

Methods Enzymol.

J. Biol. Chem.

Free Radic. Biol. Med.

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

J. Biol. Chem.

FEBS Lett.

Biochem. Biophys. Res. Commun.

Age related changes in the rotator cuff

Br. J. Rheum.

Tendon degeneration and chronic shoulder pain: Changes in the collagen composition of the human rotator cuff tendons in rotator cuff tendinitis

Ann. Rheum. Dis.

Glycosaminoglycans of human rotator cuff tendons: Changes with age and in chronic rotator cuff tendinitis

Ann. Rheum. Dis.

Cellular defenses against damage from reactive oxygen species

Physiol. Rev.

Mitochondria and apoptosis

Eur. J. Biochem.

Regular Article
Antioxidant Enzyme Peroxiredoxin 5 Is Upregulated in Degenerative Human Tendon