Short CommunicationsINDOMETHACIN MODULATES CIRCULATING CYTOKINE RESPONSES TO STRENUOUS EXERCISE IN HUMANS
References (56)
- et al.
Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages
Biochem Biophys Res Commun
(1986) - et al.
Inhibition of leukocyte adhesion: an alternative mechanism of action for anti-inflammatory drugs
Immunol Today
(1998) - et al.
Stress, cytokine patterns and susceptibility to disease
Baillieres Best Pract Res Clin Endocrinol Metab
(1999) - et al.
Effect of nonsteroidal antiinflammatory drugs on immune function
Semin Arthritis Rheum
(1983) - et al.
Inhibition of tumour necrosis factor production in endotoxin-stimulated human mononuclear leukocytes by the prostacyclin analogue iloprost: cellular mechanisms
Cytokine
(1997) - et al.
Prostaglandin E2 regulates macrophagederived tumor necrosis factor gene expression
J Biol Chem
(1988) - et al.
Cytokines and cytokine receptors in health and disease
Cytokine
(1993) Nonsteroidal anti-inflammatory drugs: new perspectives on a familiar drug class
Nurs Clin North Am
(2000)- et al.
Cyclooxygenase inhibitors enhance tumour necrosis factor production and mortality in murine endotoxic shock
Cytokine
(1994) - et al.
Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats
Gastroenterology
(1995)
Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists
Biochem Pharmacol
Differential sensitivity of in vivo TNF and IL-6 production to modulation by anti-inflammatory drugs in mice
Int J Immunopharmacol
Effect of indomethacin on the kinetics of tumour necrosis factor alpha release and tumour necrosis factor alpha gene expression by human blood monocytes
Pharmacol Res
The effects of nonsteroidal anti-inflammatory drugs on immune functions of human peripheral blood mononuclear cells
Immunopharmacology
Nonsteroidal anti-inflammatory drugs differentially regulate cytokine production in human lymphocytes: up-regulation of TNF, IFN-gamma and IL-2, in contrast to down-regulation of IL-6 production
Cytokine
Mechanism of action of nonsteroidal anti-inflammatory drugs
Am J Med
Effect of brief maximal exercise on circulating levels of interleukin-12
Eur J Appl Physiol
Inhibition of murine natural killer cell activity by prostaglandins
J Immunol
Are similar inflammatory factors involved in strenuous exercise and sepsis?
Intensive Care Med
Inflammatory cytokines in nonpathological states
News Physiol Sci
In vitro production of IL 1 beta, IL 1 alpha, TNF and IL2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation
Eur J Immunol
Oral aspirin and ibuprofen increase cytokine-induced synthesis of IL-1 beta and of tumour necrosis factor-alpha ex vivo
Immunol
Circulating levels of peripheral blood leucocytes and cytokines following competitive cycling
Can J Appl Physiol
Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity
Biol Pharm Bull
Cytokine production ex vivo: effect of raised body temperature
Int J Hyperthermia
Inhibition by cyclo-oxygenase inhibitors of interleukin-6 production by human peripheral blood mononuclear cells
Int J Immunopharmacol
Inhibition of NF-kappa B by sodium salicylate and aspirin
Science
Effect of indomethacin on selected immune parameters in different age groups of mice
Physiol Res
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Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults
2016, Molecular Aspects of MedicineCitation Excerpt :Moreover, supplementation with different antioxidants alleviates the increase in systemic IL-6 in response to exercise in human contracting skeletal muscle (Fischer et al., 2004). In a similar way, the administration of anti-inflammatory drugs, which inhibit NF-κB activity, diminish the exercise induced increase of IL-6, supporting that NF-κB may represent the possible link between contractile activity and IL-6 synthesis (Kopp and Ghosh, 1994; Rhind et al., 2002). The underpinning mechanisms of age-associated chronic inflammation and frailty remain elusive.
Supplementation with a whey protein hydrolysate enhances recovery of muscle force-generating capacity following eccentric exercise
2010, Journal of Science and Medicine in SportCitation Excerpt :It is likely that the large variation in the CK response between volunteers also contributed to the lack of ability to detect a significant change since, while there was overall a mean increase in CK levels by 24 h post-ECC in all treatment groups, this was not statistically significant, suggesting a lack of statistical power to detect any significant changes. The lack of any effect of ECC on plasma TNFα, might have been due to the relatively short duration of the exercise protocol employed, since the majority of studies reporting elevations in TNFα concentrations have employed longer duration exercise interventions (i.e. >2 h) to induce muscle damage.7 However, the initial development of muscle soreness, and its persistence throughout the study period in all volunteers, including those who consumed the hydrolysate, suggests that some level of muscle damage and/or inflammation may have been present in all treatment groups, but this did not manifest in changes in circulating markers of inflammation or muscle damage within the timeframe of the protocol.
Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6: A randomized, double-blind, placebo-controlled study
2008, Brain, Behavior, and ImmunityCitation Excerpt :Propranolol injected to rats prior to tailshock stress (Johnson et al., 2005) or the stress of open field exposure (Soszynski et al., 1996) significantly reduced increase in plasma IL-6 levels. In healthy subjects, treatment for 5 days with the non-steroidal anti-inflammatory drug indomethacin significantly attenuated exercise-induced increase in plasma IL-6 levels (Rhind et al., 2002). However, to our knowledge, whether aspirin and propranolol affect the plasma IL-6 response to acute psychosocial stress in humans has not yet been investigated.
Are biomarkers associated with sensitivity to physical activity?
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Present address: Faculty of Physical Education & Recreation Studies, University of Manitoba, R3N 0V1, Canada
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Correspondence to: Pang N. Shek, Ph.D. Operational Medicine Section, DRDC–Toronto (formerly DCIEM), 1133 Sheppard Avenue West, Toronto, Ontario, M3M 3B9, Canada