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The role of pulmonary CO2 flow in the control of the phase i ventilatory response to exercise in humans

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Abstract

To gain an insight into the origin of the phase I ventilatory response to exercise (ph I) in humans, pulmonary ventilation WE) and end-tidal partial pressures of oxygen and carbon dioxide (P ETO2 and P ETCO2, respectively) were measured breath-by-breath in six male subjects during constant-intensity exercise on the cycle ergometer at 50, 100 and 150 W, with eupnoeic normocapnia (N) or hyperpnoeic hypocapnia (H) established prior to the exercise test. Cardiac output (Q2) was also determined beat-by-beat by impedance cardiography on eight subjects during moderate exercise (50 W), and the C02 flow to the lungs (Q2·CvCO2 where CvCO2 is concentration of CO2 in mixed veneous blood) was estimated with a time resolution of one breathing cycle. In N, the initial abrupt increase of PE during ph I (ΔVE approximately 18 l · min−1 above rest) was followed by a transient fall. When P ETCO2 started to increase (and P ETO2 decreased) VE increased again (phase II ventilatory response, ph II). In H, during ph I ΔVE was similar to that of N. By contrast, during ph II ΔVE kept gradually decreasing and started to increase only when P ETCO2 had returned to approximately 40 mmHg (5.3 kPa). Thus, as a result of the prevailing initial conditions (N or H) a temporal shift of the time-course of VE during ph II became apparent. No correlation was found between C02 flow to the lungs and VE during ph I. These results are interpreted as suggesting that an increased C02 flow to the lungs does not constitute an important factor for the initial hyperventilatory response to exercise. They are rather compatible with a neural origin of ph I, and would support the “neurohumoral” theory of ventilatory control during exercise.

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Cerretelli, P., Grassi, B., Xi, L. et al. The role of pulmonary CO2 flow in the control of the phase i ventilatory response to exercise in humans. Europ. J. Appl. Physiol. 71, 287–294 (1995). https://doi.org/10.1007/BF00240406

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