Summary
No data exists regarding responses of human atrial natriuretic factor (ANF) to exercise in the heat. The purpose of this study was to examine the responses of plasma ANF to high intensity submaximal (71%±0.9 \(\dot V_{{\text{O}}_{{\text{2 max}}} } \)) exercise in the heat over an eight day acclimation period. Fourteen healthy males volunteered to participate in the study. Subjects performed intermittent exercises on a treadmill (0% grade) during 50 min of each 100 min trial in an environmental chamber maintained at 41.2±0.5° C, 39.0±1.7% relative humidity. Blood was obtained from an antecubital vein after standing 20 min in the heat prior to exercise, and immediately after exercise. Measures were compared on days 1, 4 and 8. ANF did not change pre- to post-exercise nor did it change over the eight day heat acclimation period despite other heat acclimation adaptations. Conversely, plasma aldosterone (ALDO), renin activity (PRA) and cortisol (COR) all increased (p<0.05) pre- to post-exercise on each day but again no changes were observed over the eight day period. These data support that ANF may not increase when ALDO and PRA increases are observed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ackermann U, Trizawa TG, Milojeric S, Sonnenberg H (1984) Cardiovascular effects of atrial extracts in anesthetized rats. Can J Physiol Pharmacol 62:819–826
Armstrong LE, Dziados JE (1986) Effects of heat exposure on the exercising adult. In: Bernhardt DB (ed) Sports physical therapy. Churchill Livingstone, New York, pp 197–215
Atarashi K, Mulrow PJ, Franco-Saenz R, Snajdar R, Rapp J (1984) Inhibition of aldosterone production by an atrial extract. Science 224:992–994
Burnett JC, Kao PC, Hu DC, Heser DW, Heublein D, Granger JP, Opgenorth TJ, Reeder GS (1986) Atrial natriuretic peptide elevation in congestive heart failure in the human. Science 231:1145–1147
Campbell W, Currie M, Needleman P (1985) Inhibition of aldosterone biosynthesis by atriopeptins in rat adrenal cells. Circ Res 57:113–118
Chartier L, Schiffrin EL, Thibault G (1984) Effects of atrial natriuretic factor (ANF)-related peptides on aldosterone secretion by adrenal glomerulosa cells: critical role of the intra molecular disulphide bond. Biochem Biophys Res Commun 122:171–174
Collins KJ, Weiner JS (1986) Endocrinological aspects of exposure to high environmental temperatures. Physiol Rev 48:785–839
DeBold AJ, Borenstein HB, Veress AT, Sonnenberg HA (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28:89–94
DeLean A, Racz K, Gutkowska J, Nguyen TT, Cantin M, Genest J (1984) Specific receptor-mediated inhibition by synthetic atrial natriuretic factor of hormone-stimulated steroidogenesis in cultured bovine adrenal cells. Endocrinology 115:1636–1638
Dill DB, Costill DL (1974) Calculation of percentage changes in volume of blood, plasma and red cells in dehydration. J Appl Physiol 37:241–248
Finberg JPM, Berlyne GM (1976) Renin and aldosterone secretion following acute environmental heat exposure. Israel J Med Sci 12:844–847
Francesconi RP, Sawka MN, Pandolf KB, Hubbard RW, Young AJ, Muza S (1985) Plasma hormonal responses at graded hypohydration levels during exercise-heat stress. J Appl Physiol 59:1855–1860
Goodfriend TL, Elliott ME, Atlas SA (1984) Actions of synthetic atrial natriuretic factor on bovine adrenal glomerulosa. Life Sci 35:1675–1682
Greenleaf JE, Greenleaf CJ (1970) Human acclimatization to heat — a compendium of research NASA Technical Memorandum. Moffett Field, CA No. TMX-62008, pp 1–188
Kirby CR, Covertino VA (1986) Plasma aldosterone and sweat sodium concentrations after exercise and heat acclimation. J Appl Physiol 61:967–970
Kosunen KF, Pakarienen AJ, Kuoppasalmi K, Adlercreutz H (1976) Plasma renin activity, angiotensin II, and aldosterone during intense heat stress. J Appl Physiol 41:323–327
Kudo T, Baird A (1984) Inhibition of aldosterone production in the adrenal glomerulosa by atrial natriuretic factor. Nature 312:756–757
Zambraski EJ, Tucker MS, Lakas CS, Grassl SM, Scanes CG (1984) Mechanism of renin release in exercising dog. Am J Physiol Endocrinol Metab 246:E71-E76
Zimmerman RS, Gharib H, Zimmerman D, Heublein D, Burnett JC (1987) Atrial natriuretic peptide in hypothyriodism. J Clin Endocrin and Metab 64:353–355
Author information
Authors and Affiliations
Additional information
Human subjects participated in these studies after giving their free and informed voluntary consent. Investigators adhered to AR 70-25 and USAMRDC Regulation 70-25 on Use of Volunteers in Research. The views, opinions, and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy, or decision, unless so designated by other official documentation
Rights and permissions
About this article
Cite this article
Kraemer, W.J., Armstrong, L.E., Hubbard, R.W. et al. Responses of plasma human atrial natriuretic factor to high intensity submaximal exercise in the heat. Europ. J. Appl. Physiol. 57, 399–403 (1988). https://doi.org/10.1007/BF00417983
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00417983