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Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions

  • Knee
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Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Platelet-rich plasma (PRP) is a natural concentrate of autologous blood growth factors experimented in different fields of medicine in order to test its potential to enhance tissue regeneration. The aim of our study is to explore this novel approach to treat degenerative lesions of articular cartilage of the knee. One hundred consecutive patients, affected by chronic degenerative condition of the knee, were treated with PRP intra-articular injections (115 knees treated). The procedure consisted of 150-ml of venous blood collected and twice centrifugated: 3 PRP units of 5 ml each were used for the injections. Patients were clinically prospectively evaluated before and at the end of the treatment, and at 6 and 12 months follow-up. IKDC, objective and subjective, and EQ VAS were used for clinical evaluation. Statistical analysis was performed to evaluate the significance of sex, age, grade of OA and BMI. A statistically significant improvement of all clinical scores was obtained from the basal evaluation to the end of the therapy and at 6–12 months follow-up (P < 0.0005). The results remained stable from the end of the therapy to 6 months follow up, whereas they became significantly worse at 12 months follow up (P = 0.02), even if still significantly higher respect to the basal level (P < 0.0005). The preliminary results indicate that the treatment with PRP injections is safe and has the potential to reduce pain and improve knee function and quality of live in younger patients with low degree of articular degeneration.

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Acknowledgments

M. Lo Presti, A. Bondi, M. Delcogliano, S. Bassini: IX Division, Biomechanics Lab, Rizzoli Orthopaedic Institute, Bologna, Italy. A. Gabriele, F. Pieretti, M. Vaccari, A.M. Del Vento, M. Zagarella, V. Roverini, I. Brognara, L. D’Amato, S. Ardone: Immunohematology and Transfusion Medicine Service, Rizzoli Orthopaedic Institute, Bologna, Italy. E. Pignotti, K. Smith: Task Force, Rizzoli Orthopaedic Institute, Bologna, Italy.

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Authors and Affiliations

  1. Biomechanics Laboratory, Department of Orthopaedic and Sports Trauma, Rizzoli Orthopaedic Institute, Via Di Barbiano, 1/10, 40136, Bologna, Italy

    Elizaveta Kon, Giuseppe Filardo, Alessandro Di Martino & Maurilio Marcacci

  2. VI Division, Rizzoli Orthopaedic Institute, Bologna, Italy

    Roberto Buda, Antonio Timoncini & Sandro Giannini

  3. Immunohematology and Transfusion Medicine Service, Rizzoli Orthopaedic Institute, Bologna, Italy

    Annarita Cenacchi & Pier Maria Fornasari

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  1. Elizaveta Kon
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  2. Roberto Buda
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  3. Giuseppe Filardo
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  4. Alessandro Di Martino
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  6. Annarita Cenacchi
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  7. Pier Maria Fornasari
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  8. Sandro Giannini
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  9. Maurilio Marcacci
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Correspondence to Alessandro Di Martino.

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Kon, E., Buda, R., Filardo, G. et al. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 18, 472–479 (2010). https://doi.org/10.1007/s00167-009-0940-8

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  • DOI: https://doi.org/10.1007/s00167-009-0940-8

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