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Multipotent Mesenchymal Stromal Cell Therapy and Risk of Malignancies

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Abstract

Cell therapy with Multipotent Mesenchymal Stromal Cells (MSC) holds enormous promise for the treatment of a large number of degenerative and immune/inflammatory diseases. Their multilineage differentiation potential, immunoprivilege and capacity of promoting recovery of damaged tissues coupled with anti-inflammatory and immunosuppressive properties are the focus of a multitude of clinical studies currently underway. The recognized clinical potential of MSC repairing/immunomodulatory effects now encompasses graft-versus-host disease, hematologic malignancies, cardiovascular diseases, neurologic and inherited diseases, autoimmune diseases, organ transplantation, refractory wounds, and bone/cartilage defects among others. However, it has been suggested that both the need of extensive ex vivo culture for MSC clinical use, and their proangiogenic, anti-apoptotic and immunomodulatory properties may act together as tumor promoters, raising significant safety concerns. This paper will review the available data on in vitro MSC maldifferentiation and the ability of MSC to sustain tumor growth in vivo, with the aim to clarify whether MSC-based therapeutic approaches may carry actual risk of malignancies.

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Acknowledgement

This work was supported by grants from Fondazione ART (Fondazione per la Ricerca sui Trapianti, Milan, Italy). We greatly acknowledge Drs. Martino Introna and Alessandro Rambaldi for their suggestions and helpful discussion. The authors are members of the Mesenchymal Stem Cells in Solid Organ Transplantation (MISOT) study group, www.misot.de.

Part of the research leading to this work has received funding from the European Community under the European Community’s Seventh Framework Programme (FP7/2007-2013), grant number 223007, STAR-T REK project.

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The authors declare no conflict of interest.

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Casiraghi, F., Remuzzi, G., Abbate, M. et al. Multipotent Mesenchymal Stromal Cell Therapy and Risk of Malignancies. Stem Cell Rev and Rep 9, 65–79 (2013). https://doi.org/10.1007/s12015-011-9345-4

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