Enhanced left ventricular systolic performance at high altitude during operation everest II☆
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Cardiac performance with chronic hypoxia: mechanisms regulating stroke volume
2019, Current Opinion in PhysiologyCitation Excerpt :These invasive measurements were also complemented by the use of two-dimensional echocardiography during maximal exercise. Specifically, Suarez et al. [13] reported a progressive decrease in end-diastolic volume and stroke volume with increasing altitude, but importantly also a decrease in end-systolic volume which emphasised that end-systolic elastance and contractility (estimated from end-systolic pressure/volume) was well preserved even at maximal exercise in extreme hypoxia in healthy humans. Furthermore, Fowles and Hultgren [14] normalised markers of systolic function to the decrease in LV end-diastolic diameter during altitude acclimatisation and concluded that contractile function was actually enhanced.
Altitude and the right heart
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This study was supported by Contract DAMD17-85-5208 from the Army Research and Development Command, and the Arctic Institute of North America. Computational assistance was provided by the CLINFO Project, Grant RR-00350, from the Division of Research Resources of the National Institutes of Health, Bethesda, Maryland.