General reviewOn the regulation of sex-hormone-binding globulin—A challenge of an old dogma and outlines of an alternative mechanism
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2013, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :Payne et al. [181] suggested that the concentration of cell-secreted SHBG is enhanced by TH and reduced by insulin in a dose-dependent manner. SHBG is a glycoprotein whose synthesis and secretion are regulated by the liver [182,183]. Additionally, SHBG plays a critical role in modulating steroid-induced cell growth via interactions with its receptor [184] (Fig. 3A, g).
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