Increased production of PDGF by angiotensin and high glucose in human vascular endothelium
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Cited by (32)
Research progress on the role of PDGF/PDGFR in type 2 diabetes
2023, Biomedicine and PharmacotherapyDextrose prolotherapy in knee osteoarthritis: A systematic review and meta-analysis
2021, Journal of Clinical Orthopaedics and TraumaCitation Excerpt :Investigators have also demonstrated that 20% dextrose exerted a regenerative effect in the healing of injured Achilles tendons in rats through the proliferation of fibroblasts. In human in-vitro studies, a high glucose environment resulted in increased production of platelet-derived growth factors by the vascular endothelium and mesangial cells.29,30 Proving that these processes are directly responsible for in-vivo changes in human patients remains challenging, however.
Diabetic fibrosis
2021, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :The members of the PDGF family exert potent fibrogenic actions mediated predominantly through the PDGFRα. In vitro studies and associative in vivo data suggest that high glucose may induce expression of PDGFs [94,95], while enhancing activation of PDGFRs [96,97]. Both PDGF-A and PDGF-B are induced in human diabetic kidneys [98].
Autologous Platelet-Rich Plasma Versus Dextrose Prolotherapy for the Treatment of Chronic Recalcitrant Plantar Fasciitis
2014, PM and RCitation Excerpt :A potential biologic effect of prolotherapy is supported by several clinical and animal studies, although the historical hypothesis that prolotherapy causes an inflammatory response leading to reduced tendon and ligament laxity has not been confirmed [5,13-17]. Hyperosmolar dextrose has been shown to increase platelet-derived growth factor expression and to up-regulate multiple mitogenic factors that may act as signaling mechanisms in tendon repair [18-20]. Autologous platelet-rich plasma (PRP) injection is a relatively new modality.
Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2
2004, Microvascular ResearchInhibition of Platelet-Derived Growth Factor Promotes Pericyte Loss and Angiogenesis in Ischemic Retinopathy
2004, American Journal of PathologyCitation Excerpt :However, it is unclear from this study if the rise in retinal PDGF is related to pericyte viability as morphological studies were not performed, and angiogenesis does not develop in this rodent model of diabetes.41,42 It is possible that the rise in PDGF gene expression in the retinas of diabetic rats is a response to hyperglycaemia as cultured bovine retinal pericytes and endothelial cells have been reported to increase PDGF40,43 and PDGF-β receptor44 mRNA in response to high glucose. Studies in humans with the proliferative form of diabetic retinopathy have also reported elevated levels of PDGF-AB in vitreal fluids.45