CardiomyopathyCorrelation of Precordial Voltages to Left Ventricular Mass on Echocardiogram in Adolescent Patients With Hypertrophic Cardiomyopathy Compared With that in Adolescent Athletes
Section snippets
Methods
This was a retrospective cohort study of pediatric patients evaluated for HC. This study was approved by the Cincinnati Children's Hospital Internal Review Board (study# 2013-4304). Consecutive adolescent patients aged 13 to 18 years with a history of HC from January 1, 2003, to June 30, 2013, were included. An electrocardiogram, echocardiogram, and genetic testing were part of the evaluation. Genetic testing was completed between 2008 and 2012. Patients with a gene positive family history of
Results
There were 97 patients evaluated for HC during the study period, of which 52 met criteria. Eleven patients were excluded because they were genotype and phenotype negative. Thirty-four patients were excluded because genetic testing was not completed and phenotype negative. Patient demographics are demonstrated in Table 1. Mean age was 16 years (13 to 18). Postevaluation HC classification was 21 (40%) gene+/phen+, 12 (23%) gene+/phen−, 10 (19%) gene−/phen+, and 9 (17%) genotype unknown but
Discussion
Electrocardiograms continue to be part of athletic screening programs, as well as screening for HC, although whether ECG findings of LV hypertrophy can be used to distinguish between healthy populations and those with HC remains unclear. This study finds that there is a parabolic relation between ECG LV precordial voltages and LV mass in the phenotype-positive adolescents not expressed in adolescent athlete controls. LV hypertrophy by ECG voltage criteria demonstrated poor sensitivity and was
Disclosures
The authors have no conflicts of interest to disclose.
References (21)
- et al.
Assessment of the 12-lead electrocardiogram as a screening test for detection of cardiovascular disease in healthy general populations of young people (12-25 years of age): a scientific statement from the American Heart Association and the American College of Cardiology
J Am Coll Cardiol
(2014) - et al.
Hypertrophic cardiomyopathy characterized by marked hypertrophy of the posterior left ventricular free wall: significance and clinical implications
J Am Coll Cardiol
(1991) - et al.
Phenotypic spectrum and patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy: morphologic observations and significance as assessed by two-dimensional echocardiography in 600 patients
J Am Coll Cardiol
(1995) - et al.
Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study
Am Heart J
(2003) - et al.
Relation of electrocardiographic abnormalities to evolving left ventricular hypertrophy in hypertrophic cardiomyopathy during childhood
Am J Cardiol
(1989) - et al.
Accuracy of surface electrocardiograms for differentiating children with hypertrophic cardiomyopathy from normal children
Am J Cardiol
(1999) - et al.
Comparison of total 12-lead QRS voltage in a variety of cardiac conditions and its usefulness in predicting increased cardiac mass
Am J Cardiol
(2013) - et al.
Differentiating left ventricular hypertrophy in athletes from that in patients with hypertrophic cardiomyopathy
Am J Cardiol
(2014) - et al.
Comparison of usefulness of Sokolow and Cornell criteria for left ventricular hypertrophy in subjects aged <20 years versus >30 years
Am J Cardiol
(2012) - et al.
Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults
Circulation
(1995)
Cited by (0)
See page 961 for disclosure information.