Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

Abstract

FGF, a polypeptide found in brain and pituitary, provokes the initiation of DNA synthesis by resting ST3 cells. When glucocorticoids are present FGF stimulates DNA synthesis as effectively as serum.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Van Wyk, J. S., Hall, K., Van den Brande, J. L., and Weaver, R. R., J. clin. Endocr., 32, 489 (1971).

    Article  Google Scholar 

  2. Uthne, K., Acta endocr. Copnh., Suppl. 173, (1973).

  3. Clark, J., Jones, K., Gospodarowicz, D., and Sato, G., Nature new Biol, 236, 180 (1972).

    Article  CAS  Google Scholar 

  4. Gospodarowicz, D., Jones, K., and Sato, G., Proc. natn. Acad. Sci. U.S.A. (in the press).

  5. Corvol, M., Malemud, C. J., and Sokoloff, L., Endocrinology, 90, 262 (1972).

    Article  CAS  Google Scholar 

  6. Armelin, H., Proc. natn. Acad. Sci. U.S.A., 70, 2702 (1973).

    Article  ADS  CAS  Google Scholar 

  7. Holley, R. W., and Kiernan, J. A., Proc. natn. Acad. Sci. U.S.A., 60, 300 (1968).

    Article  ADS  CAS  Google Scholar 

  8. Gospodarowicz, D., J. biol. Chem. (in the press).

  9. Gilman, A. G., and Nirenberg, M., Proc. natn. Acad. Sci. U.S.A., 68, 2165 (1971).

    Article  ADS  CAS  Google Scholar 

  10. Pfeiffer, S. E., Herschman, H. R., Lightbody, R., and Sato, G., J. Cell Physiol., 75, 329 (1970).

    Article  CAS  Google Scholar 

  11. Reisfeld, R. A., Lewis, U. J., and Williams, D. E., Nature, 195, 281 (1962).

    Article  ADS  CAS  Google Scholar 

  12. Jost, J. P., and Rickenberg, H. V., in A. Rev. Biochem., 40, 761 (1971).

    Google Scholar 

  13. Thrash, C. R., and Cunningham, D. D., Nature, 242, 399 (1973).

    Article  ADS  CAS  Google Scholar 

  14. Samuels, H. H., and Tomkins, G. H., J. molec. Biol, 52, 57 (1970).

    Article  CAS  Google Scholar 

  15. Gospodarowicz, D., Biochim. biophys. Acta, 244, 353 (1971).

    Article  CAS  Google Scholar 

  16. Gospodarowicz, D., J. biol. Chem., 241, 1314 (1973).

    Google Scholar 

  17. Hackney, J. F., Gross, S. R., Aronow, L., and Pratt, W. B., Molec. Pharmac., 6, 500 (1970).

    CAS  Google Scholar 

  18. Temin, H. M., Pierson, R. W., and Dulak, N. C., in Growth, nutrition and metabolism of cells in culture, (edit. by Cristofalo, V. I., and Rothblat, G.,) 50 (Academic Press, New York, 1972).

    Google Scholar 

  19. Paul, D., Lipton, A., and Klinger, F., Proc. natn. Acad. Sci. U.S.A., 68, 645 (1971).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gospodarowicz, D. Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature 249, 123–127 (1974). https://doi.org/10.1038/249123a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/249123a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing