Do small heat shock proteins protect skeletal muscle from injury?

Exerc Sport Sci Rev. 2002 Jul;30(3):117-21. doi: 10.1097/00003677-200207000-00005.

Abstract

Prior exercise training protects skeletal muscle from contraction-induced injury. However, the mechanisms of protection are unknown. In this paper, the hypothesis is developed that exercise-induced increases in small heat shock protein activity may protect muscle cells via interactions with cytoskeletal elements and/or the glutathione system.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytoprotection / physiology
  • Exercise / physiology
  • Glutathione / physiology
  • Heat-Shock Proteins / physiology*
  • Humans
  • Muscle Contraction / physiology
  • Muscle, Skeletal / injuries
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiology*
  • United States
  • Wounds and Injuries / prevention & control*

Substances

  • Heat-Shock Proteins
  • Glutathione