The neuromuscular consequences of anterior cruciate ligament (ACL) injury are important considerations because these deficits play a crucial role in a patient's recovery following ACL injury or reconstruction. The purpose of this article is to review and synthesize the known neuromuscular consequences of ACL injury and reconstruction. Specifically, changes in somatosensation, muscle activation, muscle strength, atrophy, balance, biomechanics, and patient-oriented outcomes are discussed. Understanding neuromuscular consequences aids in the construction of optimized rehabilitation strategies.