The primary objective of this pilot study was to explore the feasibility of implementing two exercise programs for female patients who are breast cancer survivors and residents of the metropolitan area of San Juan, Puerto Rico. Potential benefits and complications of participating in a gym-exercise program or a home-exercise program, as opposed to standard care, were identified. Participants were randomly assigned to 1 of 3 groups: a gym-exercise group, a home-exercise group, or a non-exercise group. Interventions consisted of exercise programs with both aerobic and strengthening components, offered for a 26-week period. Outcome measures consisted of functional evaluation, shoulder range of motion, 12-minute walk test, handgrip strength, body mass index, and quality of life. The results of this study showed that it is feasible for Puerto Rican women to participate in a moderate intensity exercise program without developing complications. Participation in the exercise programs studied here minimized the side effects after cancer treatment, such as reduced physical functional ability and restricted shoulder mobility. Improvements were found in the measures of shoulder range of motion, upper extremity related physical function, and distance walked.