Let’s Get Moving (LGM) represents a structured approach to physical activity promotion in the primary care setting in the United Kingdom. LGM was developed based on a systematic review which recommended the use of key strategies to support behaviour change, including: a short counselling session; written educational resources; and follow-up support. These findings provided the basis for the programme components and the specific protocols were refined in consultation with a representative group of health professionals. Key learning centred on how to translate the scientific evidence into a practical intervention in routine primary care practice.