Cell culture studies have implicated the oxygen-sensitive hypoxia-inducible factor (HIF)
prolyl hydroxylase PHD3 in the regulation of neuronal apoptosis. To better understand this …

Hypoxia-inducible factors are the universal cellular oxygen-sensitive transcription factors
that activate a number of hypoxia responsive genes, some of which are responsible for …

Objective To examine patterns of mortality among climbers on Mount Everest over an 86
year period. Design Descriptive study. Setting Climbing expeditions to Mount Everest, 1921 …

Background: Acute mountain sickness may be caused by cerebrovascular fluid leakage due
to oxidative damage to the endothelium. This may be reduced by oral antioxidant …

Background Transplant surgery is facing a shortage of deceased donor organs. In response,
the criteria for organ donation have been extended, and an increasing number of organs …

Objective: To investigate the association of optic nerve sheath diameter (ONSD), as a
correlate of intracranial pressure (ICP), with acute mountain sickness (AMS). Design …

Abstract Stewart J. Jackson, James Varley, Claudia Sellers, Katherine Josephs, Lucy
Codrington, Georgina Duke, Marina A. Njelekela Gordon Drummond, Andrew I. Sutherland …

In recent years, there has been a shift in the donor demographics with an increase in
donation after circulatory death (DCD). Livers obtained from DCD donors are known to have …

Abstract Bates, Matthew GD, AA Roger Thompson, Kenneth Baillie, Andrew I. Sutherland,
John B. Irving, NikhillHirani, and David J. Webb. Sildenafil citrate for the prevention of high …

It used to be thought that it would be physiologically impossible to climb Mount Everest with
or without oxygen. In 1953 Hillary and Tenzing proved that it was possible to reach the …