Anterior cruciate ligament tears are common and affect young individuals who participate in
jumping and pivoting sports. After injury many individuals undergo ligament reconstruction …

Highlights•HLH is a life-threatening hyperinflammatory syndrome.•Genetic defects impairing
lymphocyte cytotoxicity mainly cause primary HLH.•Defects primary impairing macrophages …

Intracellular Toll-like receptor 3 (TLR3), TLR7, and TLR9 localize in endosomes and
recognize single-stranded RNA and nucleotides from viruses and bacteria. This interaction …

Background Shoulder instability in athletics is a common occurrence. However, there is
controversy as to whether non-operative versus operative management is the most effective …

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome, characterized by
severe hyperinflammation and immunopathological manifestations in several tissues. These …

The mechanisms that induce Alzheimer's disease (AD) are largely unknown thereby
deterring the development of disease-modifying therapies. One working hypothesis of AD is …

Alzheimer disease is a progressive neurodegenerative brain disorder that leads to major
debilitating cognitive deficits. It is believed that the alterations capable of causing brain …

Subcutaneous panniculitis-like T cell lymphoma (SPTCL), a non-Hodgkin lymphoma, can be
associated with hemophagocytic lymphohistiocytosis (HLH), a life-threatening immune …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a critical regulator of cell
death and inflammation, but its relevance for human disease pathogenesis remains elusive …

N-methyl-d-aspartate receptors (NMDARs) are known to regulate axonal refinement and
dendritic branching. However, because NMDARs are abundantly present as tri-heteromers …