Effects of an oral contraceptive (norgestimate/ethinyl estradiol) on bone mineral density in women with hypothalamic amenorrhea and osteopenia: an open-label …
MP Warren, KK Miller, WH Olson, SK Grinspoon… - Contraception, 2005 - Elsevier
OBJECTIVE: The effects of long-term triphasic oral contraceptive administration on bone
mineral density (BMD) were investigated in premenopausal women with hypothalamic
amenorrhea (HA) and osteopenia. METHODS: After completing three 28-day cycles in the
double-blind phase of a placebo-controlled trial, women (mean age, 26.7 years) who
received norgestimate 180–250 μg/ethinyl estradiol 35 μg (NGM/EE, n= 15) or placebo (n=
12) in the double-blind phase were to receive open-label NGM/EE for 10 additional cycles …
mineral density (BMD) were investigated in premenopausal women with hypothalamic
amenorrhea (HA) and osteopenia. METHODS: After completing three 28-day cycles in the
double-blind phase of a placebo-controlled trial, women (mean age, 26.7 years) who
received norgestimate 180–250 μg/ethinyl estradiol 35 μg (NGM/EE, n= 15) or placebo (n=
12) in the double-blind phase were to receive open-label NGM/EE for 10 additional cycles …