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Biochemical changes as a result of prolonged strenuous exercise
  1. D E R Warburton,
  2. R C Welsh,
  3. M J Haykowsky,
  4. D A Taylor,
  5. D P Humen
  1. Division of Cardiology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
  1. Correspondence to:
    Dr Warburton, Allan McGavin Sports Medicine Centre, 3055 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;


Objective: To briefly review biochemical changes that may result from prolonged strenuous exercise and to relate these changes to health risk.

Methods: Medline and Sports Discus databases were searched for relevant articles. Additional articles were found using cross referencing and the authors' knowledge of the subject area.

Results: Prolonged strenuous exercise may result in a series of biochemical changes that are of concern from a health point of view. Generally, these changes are benign, but some, especially hyponatraemia, are potentially life threatening occurrences.

Conclusion: Doctors and athletes should be aware of the potentially adverse biochemical changes, especially hyponatraemia, that may result from prolonged strenuous exercise.

  • exercise
  • hyponatraemia
  • biochemical changes

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