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  • Significant association between fluctuations in serum urate and high density lipoprotein cholesterol during exhaustive training

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Research letter
Significant association between fluctuations in serum urate and high density lipoprotein cholesterol during exhaustive training
  1. H Yanai1,
  2. M Morimoto2
  1. 1Department of Medicine, Sapporo Self-Defense Force Hospital, Sapporo, Japan
  2. 2College of Medical Technology, Hokkaido University, North-12, West-5, Sapporo 060-0812, Japan; mie@cme.hokudai.ac.jp
  1. Correspondence to:
 Assistant Professor Morimoto

https://doi.org/10.1136/bjsm.37.4.370

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    Physical training is generally considered to increase serum high density lipoprotein cholesterol (HDL-C) levels.1 However, how exhaustive training influences serum HDL-C levels remains unknown. Intense exercise increases oxygen consumption and free radical formation, and induces oxidation of low density lipoprotein (LDL).2 HDL plays an important protective role in LDL oxidation.3 An imbalance between free radical production and antioxidants is considered to lead to oxidation of LDL and subsequent alterations in serum HDL metabolism. This study investigates changes in serum urate, which is the most important intrinsic antioxidant,4 and serum lipids in male athletes after three weeks of exhaustive training.

    We measured fasting serum lipids …

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