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What do we mean by the term “inflammation”? A contemporary basic science update for sports medicine
  1. A Scott1,
  2. K M Khan1,
  3. C R Roberts1,
  4. J L Cook2,
  5. V Duronio1
  1. 1University of British Columbia, Vancouver, Canada
  2. 2LaTrobe University, Melbourne, Australia
  1. Correspondence to:
 A Scott
 University of British Columbia, 2633 Tennis Crescent, Vancouver V6T 2C1, Canada;


Most practicing sports medicine clinicians refer to the concept of “inflammation” many times a day when diagnosing and treating acute and overuse injuries. What is meant by this term? Is it a “good” or a “bad” process? The major advances in the understanding of inflammation in recent years are summarised, and some clinical implications of the contemporary model of inflammation are highlighted.

  • inflammation
  • injury
  • pathophysiology
  • anti-inflammatory drugs
  • bFGF, basic fibroblast growth factor
  • CGRP, calcitonin gene related peptide
  • COX, cyclooxygenase
  • EGF, endothelial growth factor
  • IL, interleukin
  • MCP, monocyte chemoattractant protein
  • MMP, matrix metalloproteinase
  • NGF, nerve growth factor
  • NSAID, non-steroidal anti-inflammatory drug
  • PDGF, platelet derived growth factor
  • PG, prostaglandin
  • SP, substance P
  • TGF, transforming growth factor
  • TNF, tumour necrosis factor
  • VEGF, vascular endothelial growth factor

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