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Muscle dysfunction versus wear and tear as a cause of exercise related osteoarthritis: an epidemiological update
  1. Ian Shrier
  1. Correspondence to:
 Dr Shrier
 Lady David Institute for Medical Research, Centre for Clinical Epidemiology and Community Studies, SMBD-Jewish General Hospital, 3755 Cote Sainte-Catherine Road, Montreal H3T 1E2, Canada; ian.shrier{at}


There are two main hypotheses for the cause of exercise related osteoarthritis: wear and tear of the articular cartilage and muscle dysfunction. This is a review of the clinical literature to see which hypothesis has the greatest support. Clinical studies support the muscle dysfunction hypothesis over the wear and tear hypothesis.

  • OA, osteoarthritis
  • OR, odds ratios
  • RR, relative risk
  • HR, hazard ratio
  • 95%CI, 95% confidence intervals
  • ACL, anterior cruciate ligament
  • Exp, exercise group
  • Con, control group
  • osteoarthritis
  • exercise
  • injury

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