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Do non-steroidal anti-inflammatory drugs adversely affect stress fracture healing? A short review
  1. P Wheeler1,
  2. M E Batt2
  1. 1Leicester General Hospital, Leicester, UK
  2. 2Queens Medical Centre, Nottingham, UK
  1. Correspondence to:
 Dr Wheeler
 Leicester General Hospital, University Hospital of Leicester NHS Trust, Department of Sports Medicine, Gwendolen Road, Leicester LE5 4PW, UK;


A literature search was performed to determine whether non-steroidal anti-inflammatory drugs (NSAIDs) adversely affect the healing of stress fractures. Evidence exists from laboratory studies and animal subjects that NSAIDs can affect fracture healing. This link has not been proved or disproved in human subjects, particularly for stress fractures. In view of the high usage of NSAIDs in treating musculoskeletal disorders, research is required to investigate whether the healing of stress fractures is affected by these drugs.

  • non-steroidal anti-inflammatory drugs
  • stress fracture
  • healing

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  • Competing interests: none declared